Compounds and methods for treating inflammatory disorders

Patent metadata

Field	Value
Publication number	US-12398093-B2
Application number	US-202017603091-A
Country	US
Kind code	B2
Filing date	Apr 13, 2020
Priority date	Apr 12, 2019
Publication date	Aug 26, 2025
Grant date	Aug 26, 2025

Abstract

The invention features compounds and pharmaceutical compositions having anti-inflammatory properties. Also provided are methods of using the compounds or compositions of the invention for treating an inflammatory disorder in a subject in need thereof.

First claim

What is claimed is:

1. A compound of formula (I):

or a pharmaceutically acceptable acid addition salt or prodrug thereof.

2. A pharmaceutical composition comprising the compound of claim 1 , and a pharmaceutically acceptable excipient.

3. A method of treating an inflammatory disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 1 .

4. The method of claim 3 , wherein the compound is administered in an amount less than 20 μg/kg body weight.

5. The method of claim 3 , wherein the compound is administered orally, intranasally, or by inhalation at a frequency of one to three times per week.

6. The method of claim 3 , wherein the inflammatory disorder is selected from the group consisting of asthma, chronic obstructive pulmonary disease, neuroinflammation, rheumatoid arthritis, atherosclerosis, psoriasis, type II diabetes, inflammatory bowel disease, Crohn's disease, multiple sclerosis, septicemia, and conjunctivitis.

7. A compound of formula (II):

or a pharmaceutically acceptable acid addition salt or prodrug thereof.

8. A pharmaceutical composition comprising the compound of claim 7 and a pharmaceutically acceptable excipient.

9. A method of treating an inflammatory disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 7 .

10. The method of claim 9 , wherein the compound is administered in an amount less than 20 μg/kg body weight.

11. The method of claim 9 , wherein the compound is administered orally, intranasally, or by inhalation at a frequency of one to three times per week.

12. The method of claim 9 , wherein the inflammatory disorder is selected from the group consisting of asthma, chronic obstructive pulmonary disease, neuroinflammation, rheumatoid arthritis, atherosclerosis, psoriasis, type II diabetes, inflammatory bowel disease, Crohn's disease, multiple sclerosis, septicemia, and conjunctivitis.

13. A compound of formula (III):

or a pharmaceutically acceptable acid addition salt or prodrug thereof.

14. A pharmaceutical composition comprising the compound of claim 13 and a pharmaceutically acceptable excipient.

15. A method of treating an inflammatory disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the compound of claim 13 .

16. The method of claim 15 , wherein the compound is administered in an amount less than 20 μg/kg body weight.

17. The method of claim 15 , wherein the compound is administered orally, intranasally, or by inhalation at a frequency of one to three times per week.

18. The method of claim 15 , wherein the inflammatory disorder is selected from the group consisting of asthma, chronic obstructive pulmonary disease, neuroinflammation, rheumatoid arthritis, atherosclerosis, psoriasis, type II diabetes, inflammatory bowel disease, Crohn's disease, multiple sclerosis, septicemia, and conjunctivitis.

Assignees

• Univ Louisiana State

Inventors

• Nichols Charles D
• Billac Gerald
• Nichols David E

Classifications

• A61K31/137 Primary

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• C07C2601/02

  with a three-membered ring · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P11/06

  Antiasthmatics · CPC title