Reinforced component for cell cultivation bioreactor

Patent metadata

Field	Value
Publication number	US-12397298-B2
Application number	US-202017626969-A
Country	US
Kind code	B2
Filing date	Jun 30, 2020
Priority date	Jul 16, 2019
Publication date	Aug 26, 2025
Grant date	Aug 26, 2025

Abstract

The present invention relates to a bioprocess bag 118 comprising a bag wall defining an enclosed volume for holding biomaterials. The bag wall comprises at least one inlet port 142 and at least one outlet port 146 . The bioprocess bag 118 also comprises a tube structure 400 comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure 400 comprising a reinforced portion 402 proximate the first opened-end.

First claim

The invention claimed is:

1. A bioprocess bag comprising:
a bag wall defining an enclosed volume for holding biomaterials, the bag wall comprising at least one inlet port and at least one outlet port; and
a tube structure comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure comprising a reinforced portion proximate the first opened-end, wherein the reinforced portion comprises a ribbed structure.

2. The bioprocess bag of claim 1 , wherein the second distal end is a closed-end, and the tube is adapted to accept a probe for measuring one or more properties of the biomaterials.

3. The bioprocess bag of claim 2 , wherein the probe comprises a thermocouple or resistance temperature detector (RTD).

4. The bioprocess bag of claim 1 , wherein the tube structure comprises a first opened-end proximate the bag wall and a second distal end extending into the enclosed volume, the reinforced portion proximate the first opened-end.

5. The bioprocess bag of claim 1 , wherein the tube structure is adapted to accept a sparging wand.

6. The bioprocess bag of claim 1 , wherein the ribbed structure comprises a pattern of sections that are raised relative to the tube outer surface, and the raised sections contacting each other when the tube structure is bent.

7. The bioprocess bag of claim 6 , wherein the contact of the raised sections prevents crimping of the tube structure.

8. The bioprocess bag of claim 1 , wherein the tube structure comprises a predominantly cylindrical inner wall, and a notch extending at least a portion of the length of the inner wall.

9. The bioprocess bag of claim 8 , wherein the notch defines a channel that allows air to flow out when a probe is inserted into the tube structure.

10. The bioprocess bag of claim 1 , wherein the bag wall comprises one or more of: an impeller, a heater, and/or a gas outlet.

11. A bioprocess bag comprising:
a bag wall defining an enclosed volume for holding biomaterials, the bag wall comprising at least one inlet port and at least one outlet port; and
a tube structure comprising a first opened-end proximate the bag wall and a second distal end, the tube extending into the enclosed volume, and the tube structure comprising a reinforced portion proximate the first opened-end, wherein the tube structure comprises a predominantly cylindrical inner wall, and a notch extending at least a portion of the length of the inner wall.

12. The bioprocess bag of claim 11 , wherein the notch defines a channel that allows air to flow out when a probe is inserted into the tube structure.

13. The bioprocess bag of claim 11 , wherein the second distal end is a closed-end, and the tube is adapted to accept a probe for measuring one or more properties of the biomaterials.

14. The bioprocess bag of claim 13 , wherein the probe comprises a thermocouple or resistance temperature detector (RTD).

15. The bioprocess bag of claim 11 , wherein the tube structure comprises a first opened-end proximate the bag wall and a second distal end extending into the enclosed volume, the reinforced portion proximate the first opened-end.

16. The bioprocess bag of claim 11 , wherein the tube structure is adapted to accept a sparging wand.

17. The bioprocess bag of claim 11 , wherein the ribbed structure comprises a pattern of sections that are raised relative to the tube outer surface, and the raised sections contacting each other when the tube structure is bent.

18. The bioprocess bag of claim 17 , wherein the contact of the raised sections prevents crimping of the tube structure.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Tuohey Colin
• Stankowski Ralph

Classifications

• C12M41/12

  of temperature (controlling the temperature of chemical or physical processes B01J19/0013, heating or cooling apparatus for laboratory use B01L7/00) · CPC title

• C12M29/00

  Means for introduction, extraction or recirculation of materials, e.g. pumps (pumps per se F04B) · CPC title

• C12M23/26

  flexible (flexible containers for laboratory use B01L3/505) · CPC title

• C12M23/14 Primary

  Bags · CPC title

• B01L2400/0475

  specific mechanical means and fluid pressure · CPC title