Lipid microcapsules preferably comprising a lipophilic active substance and composition containing same, method for the production thereof, and use of same in dermatology and in cosmetics
US-2016303005-A1 · Oct 20, 2016 · US
High-content and sustained-release retinoid capsule, and composition for reducing wrinkles, containing same
US12390402B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12390402-B2 |
| Application number | US-201917311129-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 4, 2019 |
| Priority date | Dec 4, 2018 |
| Publication date | Aug 19, 2025 |
| Grant date | Aug 19, 2025 |
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- Title
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Abstract
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Provided is a composition for improving wrinkles including a high-content/sustained-release retinoid capsule. The high-content/sustained-release retinoid capsule according to the presently claimed subject matter can minimize skin side effects and maximize wrinkle improvement effects by significantly increasing the retinoid content in the capsule and stability and controlling the release rate.
First claim
Opening claim text (preview).
The invention claimed is: 1. A core-shell structured retinoid capsule particle comprising a solid lipid shell; and a liquid lipid core, wherein the liquid lipid core comprises a retinoid and an amine compound, wherein the amine compound is one or more selected from the group consisting of stearylamine, benethamine, hexylamine, heptylamine, octylamine, chlorohexylamine, chloroheptylamine, chlorooxylamine and benzylamine, wherein the amine compound is comprised both in the solid lipid shell and the liquid lipid core, wherein the content of the retinoid is 1 to 20% by weight based on the dry weight of the retinoid capsule particle, and the content of the amine compound is 0.2-50 moles per 1 mole of the retinoid, and wherein the retinoid capsule particle is synthesized by an emulsification process under the condition of low pressure of 0.001 to 0.5 atm and high temperature of 50 to 90° C. 2. The retinoid capsule particle according to claim 1 , wherein the retinoid is one or more selected from the group consisting of retinol, retinal, retinoic acid and a retinoid derivative. 3. The retinoid capsule particle according to claim 1 , wherein the retinoid is released from the retinoid capsule particle in a sustained manner. 4. The retinoid capsule particle according to claim 1 , wherein the retinoid capsule particle has a Polydispersity Index (PDI) value of 0.3 or less, measured by using a dynamic light scattering (DLS) device. 5. A composition for improving wrinkles comprising the retinoid capsule particle according to claim 1 . 6. The composition for improving wrinkles according to claim 5 , wherein the composition is a cosmetic composition. 7. A method for improving skin wrinkles, comprising applying the cosmetic composition according to claim 6 to skin of a subject in need thereof. 8. The retinoid capsule particle according to claim 1 , wherein the retinoid is ion-bonded with the amine compound.
Assignees
Inventors
Classifications
Anti-ageing preparations · CPC title
Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms · CPC title
- A61K8/671Primary
Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal · CPC title
Amines · CPC title
- A61K8/11Primary
Encapsulated compositions · CPC title
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Frequently asked questions
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- What does patent US12390402B2 cover?
- Provided is a composition for improving wrinkles including a high-content/sustained-release retinoid capsule. The high-content/sustained-release retinoid capsule according to the presently claimed subject matter can minimize skin side effects and maximize wrinkle improvement effects by significantly increasing the retinoid content in the capsule and stability and controlling the release rate.
- Who is the assignee on this patent?
- Lg Household & Health Care Ltd, Lg Household & Healthcare Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K8/671. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 19 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).