Process for the synthesis of Furandicarboxylic acid

Patent metadata

Field	Value
Publication number	US-12384755-B2
Application number	US-202017785357-A
Country	US
Kind code	B2
Filing date	Dec 18, 2020
Priority date	Dec 19, 2019
Publication date	Aug 12, 2025
Grant date	Aug 12, 2025

Abstract

The present invention provides a process for the synthesis of Furandicarboxylic acid (FDCA) comprising heating a mixture of fructose, aqueous NaCl or KCl, solvent, methyl isobutyl ketone (MIBK) and a catalyst at a temperature in the range of 150 to 200° C. in a sealed vessel for a time period in the range of 2 to 5 hours to yield crude 5-(hydroxymethyl)furfural (5-HMF). The crude 5-HMF further reacts with a biocatalyst at a temperature in a range of 20 to 50° C. for a period at a range of 24 to 96 hours to yield FDCA, wherein the conversion of 5-HMF to FDCA is in the range of 90 to 100%.

First claim

We claim:

1. A process for the synthesis of Furandicarboxylic acid comprising the steps of:
a) heating a mixture of fructose, aqueous NaCl or KCl, a solvent, methyl isobutyl ketone (MIBK) and an acid catalyst at a temperature in a range of 150 to 200° C. in a sealed vessel for a time period in a range of 2 to 5 hours to yield crude 5-hydroxymethylfurfural (5-HMF); and
b) suspending a biocatalyst in saline followed by addition of crude 5-HMF of step (a) and followed by heating at a temperature in a range of 20 to 50° C. for a time period at a range of 24 to 96 hours to yield Furandicarboxylic acid (FDCA);
wherein the acid catalyst in step (a) is a homogeneous acid and heterogeneous acid catalyst;
wherein the conversion of 5-HMF to FDCA is in the range of 90 to 100%.

2. The process as claimed in claim 1 , wherein said homogeneous acid catalyst is selected from the group consisting of H 2 SO 4 , HCl and HNO 3 .

3. The process as claimed in claim 1 , wherein said heterogeneous acid catalyst is selected from the group consisting of Amberlyst-15, SO 4 2−/ ZrO 2 —Al 2 O 3 , GeCCl 4 and CrCl 2 .

4. The process as claimed in claim 1 , wherein the ratio of the fructose to the acid catalyst is 10:1.

5. The process as claimed in claim 1 , wherein said solvent of step (a) is selected from the group consisting of dimethyl sulfoxide, N,N-dimethylformamide and N,N-dimethylacetamide.

6. The process as claimed in claim 1 , wherein said biocatalyst of step (b) is selected from the group consisting of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes and Enterobacter cloacae.

Assignees

• Council Scient Ind Res

Inventors

• Rode Chandrashekhar Vasant
• Dharne Mahesh Shantappa
• Parate Roopa Dhanraj

Classifications

• C12R2001/01

  Bacteria or Actinomycetales {; using bacteria or Actinomycetales} · CPC title

• C12N1/205

  Bacterial isolates · CPC title

• C12R2001/22

  Klebsiella · CPC title

• C12P17/04

  containing a five-membered hetero ring, e.g. griseofulvin {, vitamin C} · CPC title

• C12P7/44

  Polycarboxylic acids · CPC title