WT1 helper peptides and combinations of WT1 helper peptide and conjugate of cancer antigen peptides

Patent metadata

Field	Value
Publication number	US-12383608-B2
Application number	US-201716464950-A
Country	US
Kind code	B2
Filing date	Nov 29, 2017
Priority date	Nov 30, 2016
Publication date	Aug 12, 2025
Grant date	Aug 12, 2025

Abstract

The present application relates to WT1 helper peptides consisting of an amino acid sequence of 9 to 30 amino acid residues including a sequence: KLSHL as part thereof, and combinations of a WT1 helper peptide and a conjugate of cancer antigen peptides.

First claim

The invention claimed is:

1. A composition or kit comprising at least one compound selected from the compound of formula (3):

or a pharmaceutically acceptable salt thereof, or a compound of formula (4):

or a pharmaceutically acceptable salt thereof,
wherein C—C are linked together by disulfide bond,
and
cancer antigen peptide D or a pharmaceutically acceptable salt thereof, wherein the cancer antigen peptide D is a peptide which induces WT1-specific helper T cells by binding to an MHC class II molecule and consisting of the amino acid sequence selected from:

(SEQ ID NO: 2)

AYPGCNKRYFKLSHL,

(SEQ ID NO: 3)

YPGCNKRYFKLSHLQ,

(SEQ ID NO: 8)

NKRYFKLSHLQMHSRK,

(SEQ ID NO: 9)

KRYFKLSHLQMHSRK,

(SEQ ID NO: 11)

RYFKLSHLQMHSRKH,

(SEQ ID NO: 12)

YFKLSHLQMHSRKHT,

(SEQ ID NO: 13)

FKLSHLQMHSRKHTG,

(SEQ ID NO: 14)

KLSHLQMHSRKHTGE,

(SEQ ID NO: 39)

RYFKLSHLQMHSRK,

(SEQ ID NO: 40)

YFKLSHLQMHSRK,

(SEQ ID NO: 41)

FKLSHLQMHSRK,

(SEQ ID NO: 42)

KLSHLQMHSRK,

(SEQ ID NO: 43)

AYPGCNKRYFKLSHLQMH,

(SEQ ID NO: 44)

AYPGCNKRYFKLSHLQMHSRK,

(SEQ ID NO: 45)

RYFKLSHLQMH,

(SEQ ID NO: 46)

GCNKRYFKLSHL,

(SEQ ID NO: 47)

FKLSHLQMHSRKHTGE,

(SEQ ID NO: 48)

RYFKLSHLQMHSRKHT,

(SEQ ID NO: 49)

RYFKLSHLQMHSRKHTGE,

(SEQ ID NO: 50)

KLSHLQMHSRKH,

(SEQ ID NO: 52)

AYPGCNKRYFKLSHLQMHSR,

(SEQ ID NO: 53)

AYPGCNKRYFKLSHLQMHS,

(SEQ ID NO: 54)

AYPGCNKRYFKLSHLQM,

(SEQ ID NO: 55)

AYPGCNKRYFKLSHLQ,

(SEQ ID NO: 56)

YFKLSHLQMHSRKHTGE,

(SEQ ID NO: 57)

RYFKLSHLQMHSRKHTG,

(SEQ ID NO: 58)

RYFKLSHLQMHSR,

(SEQ ID NO: 59)

RYFKLSHLQMHS,

(SEQ ID NO: 60)

RYFKLSHLQM,

(SEQ ID NO: 61)

YPGCNKRYFKLSHL,

(SEQ ID NO: 62)

PGCNKRYFKLSHL,

(SEQ ID NO: 63)

CNKRYFKLSHL,

(SEQ ID NO: 64)

NKRYFKLSHL,

Assignees

• Sumitomo Pharma Co Ltd
• Int Inst Cancer Immunology Inc

Inventors

• Ban Hitoshi
• Goto Masashi
• Takanashi Yosuke

Classifications

• A61K39/00 Primary

  Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53) · CPC title

• A61K39/001153 Primary

  Wilms tumor 1 [WT1] · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61K2039/572

  cytotoxic response · CPC title

• A61K2039/55566

  Emulsions, e.g. Freund's adjuvant, MF59 · CPC title