CRF receptor antagonists and methods of use

Patent metadata

Field	Value
Publication number	US-12383536-B2
Application number	US-202017764050-A
Country	US
Kind code	B2
Filing date	Sep 25, 2020
Priority date	Sep 27, 2019
Publication date	Aug 12, 2025
Grant date	Aug 12, 2025

Abstract

Compounds are provided herein, as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).

First claim

We claim the following:

1. A pharmaceutical composition comprising a compound of formula (IIa):

or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, wherein:
each R 2a is independently hydrogen or deuterium;
R 4a is

R 6a is C(R A ) 3 ; and
each R A is independently hydrogen or deuterium.

2. The pharmaceutical composition of claim 1 , wherein the compound of formula (IIa) is a compound of formula:

or a pharmaceutically acceptable salt thereof.

3. A method of treating congenital adrenal hyperplasia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of formula (IIa):

or a pharmaceutically acceptable salt thereof, wherein:
each R 2a is independently hydrogen or deuterium;

R 4a is
R 6a is C(R A ) 3 ; and
each R A is independently hydrogen or deuterium.

4. The method of claim 3 , wherein the compound of formula (IIa) is a compound of formula:

or a pharmaceutically acceptable salt thereof.

Assignees

• Neurocrine Biosciences Inc

Inventors

• Smith Evan
• Luo Sha
• Loewen Gordon Raphael
• Ashweek Neil J
• Williams John P

Classifications

• A61P5/38

  of the suprarenal hormones · CPC title

• C07B59/002

  Heterocyclic compounds · CPC title

• C07D277/42

  Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals · CPC title

• C07B2200/05

  Isotopically modified compounds, e.g. labelled · CPC title

• C07F9/65397

  having the two nitrogen atoms in positions 1 and 3 · CPC title