Ported end fitting for a liquid chromatography column with an integrated valve/tee having additional input and/or output

Patent metadata

Field	Value
Publication number	US-12379354-B2
Application number	US-202117513003-A
Country	US
Kind code	B2
Filing date	Oct 28, 2021
Priority date	Oct 28, 2020
Publication date	Aug 5, 2025
Grant date	Aug 5, 2025

Abstract

Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

First claim

The invention claimed is:

1. An end fitting for a liquid chromatography column, comprising:
an interface for a fluidic connection with a liquid chromatography column to receive output fluidic flow from the liquid chromatography column;
a first port for inputting or outputting fluidic flow;
a first fluidic path leading from the interface to the first port;
a first integrated valve positioned along the first fluidic path for opening or closing fluid flow along the first fluidic path;
a second port for inputting or outputting fluidic flow that is distinct from the output flow of the liquid chromatography column;
a second fluidic path leading from the second port to merge into the first fluidic path so that fluidic input from the second port is added to the output fluidic flow from the liquid chromatography column; and
a second integrated valve positioned along the second fluidic path for opening or closing fluid flow along the second fluidic path.

2. The end fitting of claim 1 , further comprising an integral tee, the integral providing the first fluidic path and the second fluidic path.

3. The end fitting of claim 2 , further comprising a third port and a third fluidic path for diverting output fluidic flow from the liquid chromatography column to the third port, wherein the third fluidic path is part of the integral tee.

4. The end fitting of claim 1 , further comprising a third port and a third fluidic path for diverting output fluidic flow from the liquid chromatography column to the third port.

5. The end fitting of claim 1 , wherein the first valve is a rotary valve, a ball valve, a linear shear valve, a spool valve or a pin valve.

6. The end fitting of claim 5 , further comprising a third integrated valve with a position that opens the third fluidic path and another position that closes the third fluidic path.

7. An end fitting for a liquid chromatography column, comprising:
an interface for a fluidic connection with a liquid chromatography column to receive fluidic flow from the liquid chromatography column;
a secondary port in fluid communication with the interface for either receiving input fluid flow or diverting a portion of fluidic flow from the liquid chromatography column;
a first integral valve for opening or closing fluidic flow to or from the secondary port;
multiple output ports for outputting an output fluidic flow including at least in part the output fluidic flow from the chromatography column; and
second integral valve for selecting which of the output ports receives the output fluidic flow.

8. The end fitting of claim 7 , wherein the second valve selects only a single one of the output ports to receive the output fluidic flow at a time.

9. The end fitting of claim 7 , further comprising an additional secondary port.

10. The end fitting of claim 9 , further comprising a third integrated valve controls fluidic flow with the secondary port.

11. An end fitting for a liquid chromatography column, comprising:
an interface for a fluidic connection with a liquid chromatography column to receive fluidic flow from the liquid chromatography column;
first and second secondary ports;
a first fluidic path leading to the first secondary port;
a first integral valve for controlling fluidic flow in the first fluidic path;
a second fluidic path leading to the first secondary port;
a second integral valve for controlling fluidic flow in the second fluidic path;
a third fluidic path leading from the interface to output ports; and
a third integral valve for selecting one of the output ports.

12. The end fitting of claim 11 , wherein at least one of the secondary ports is configured to divert a portion of the fluidic flow from the chromatography column.

13. The end fitting of claim 12 , wherein the third integral valve opens and closes the separate fluidic paths leading to respective ones of the output ports.

14. The end fitting of claim 11 , wherein there are separate fluidic flow paths leading to respective ones of the output ports.

15. The end fitting of claim 14 , wherein each of the integral valves is a rotary valve, a ball valve, a linear shear valve, a spool valve or a pin valve.

Assignees

• Waters Technologies Corp

Inventors

• Leveille Wade P
• Cormier Sylvain G
• Fogwill Michael O
• Michienzi Joseph D
• Musacchio Jeffrey
• Antocci Joseph D

Classifications

• G01N30/6004 Primary

  end pieces · CPC title

• G01N30/606

  with fluid access or exit ports · CPC title

• B01D15/22

  relating to the construction of the column · CPC title

• G01N30/461

  with serial coupling of separation columns · CPC title

• G01N2030/8429

  adding modificating material · CPC title