Method for culturing stem cell
US-2021040444-A1 · Feb 11, 2021 · US
Differentiation induction from human pluripotent stem cells into hypothalamic neurons
US12378518B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12378518-B2 |
| Application number | US-201716068929-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 18, 2017 |
| Priority date | Jan 22, 2016 |
| Publication date | Aug 5, 2025 |
| Grant date | Aug 5, 2025 |
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Abstract
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There is provided a method for efficient differentiation induction from human pluripotent stem cells into hypothalamic neurons. Also, provided is a method for constructing, from human pluripotent stem cells, a cellular structure in which hypothalamic tissue and pituitary tissue are integrated. A cellular structure including hypothalamic tissue is obtained by a method including the steps of: culturing an aggregate of human pluripotent stem cells in suspension in a medium containing a low concentration of a bone morphogenetic protein signal transduction pathway activating substance and a low concentration of a substance acting on the Shh signaling pathway; and further culturing the cell aggregate obtained in the step in suspension in a medium containing a low concentration of a substance acting on the Shh signaling pathway.
First claim
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The invention claimed is: 1. A method for producing a cellular structure comprising dorsal hypothalamic tissue, the method comprising the steps of: (1) culturing an aggregate of human pluripotent stem cells in suspension in a medium containing a bone morphogenetic protein signal transduction pathway activating substance and a substance acting on the Shh signaling pathway for 10 to 26 days, (2) further culturing the cell aggregate obtained in the step (1) in a medium containing a…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US12378518B2 cover?
- There is provided a method for efficient differentiation induction from human pluripotent stem cells into hypothalamic neurons. Also, provided is a method for constructing, from human pluripotent stem cells, a cellular structure in which hypothalamic tissue and pituitary tissue are integrated. A cellular structure including hypothalamic tissue is obtained by a method including the steps of: cul…
- Who is the assignee on this patent?
- Univ Nagoya Nat Univ Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0616. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 05 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).