Carbonic anhydrase inhibitors and antibiotics against multidrug resistant bacteria

Patent metadata

Field	Value
Publication number	US-12378211-B2
Application number	US-201917415899-A
Country	US
Kind code	B2
Filing date	Dec 18, 2019
Priority date	Dec 19, 2018
Publication date	Aug 5, 2025
Grant date	Aug 5, 2025

Abstract

The invention described herein generally relates to novel therapeutic compounds, and in particular to carbonic anhydrase inhibitors as a narrow spectrum antibiotics against drug resistant bacteria and methods for treating those infection diseases in mammals using the described carbonic anhydrase inhibitors or a pharmaceutical formulation thereof.

First claim

What is claimed is:

1. A method for treating a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment for said infection,

wherein
R 1 is

 or
an alkynyl, each of which is optionally substituted.

2. A method for decolonizing a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment,

wherein
R 1 is

 or
an alkynyl, each of which is optionally substituted.

3. The method of claim 1 , wherein said carbonic anhydrase inhibitor is

4. The method of claim 1 , wherein said bacterial infection is an infection caused by a vancomycin-resistant or vancomycin susceptible bacteria.

5. The method of claim 4 , wherein said bacteria is an Enterococcus species.

6. The method of claim 5 , wherein said Enterococcus species comprises Enterococcus faecium, Enterococcus faecalis, Enterococcus gallinarum, Enterococcus casseliflavus, Enterococcus durans, Enterococcus hirae, Enterococcus saccharolyticus , and Enterococcus raffinosus.

7. A compound having the formula (I)

or a pharmaceutically acceptable salt thereof, wherein
R 1 is

 or
an alkynyl, each of which is optionally substituted.

8. The compound of claim 7 , wherein said compound is

9. A pharmaceutical composition comprising one or more compounds of formula (I) according to claim 7 , or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers.

10. A pharmaceutical composition comprising one or more compounds of claim 8 , or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, for use as a medicament.

11. The method of claim 1 , wherein said compound is

12. The method of claim 2 , wherein said compound is

Assignees

• Purdue Research Foundation

Inventors

• Flaherty Daniel P
• Seleem Mohamed
• Kaur Jatinder
• Cao Xufeng

Classifications

• G06F9/544

  Buffers; Shared memory; Pipes · CPC title

• G06F9/522

  Barrier synchronisation · CPC title

• G06F9/3887

  controlled by a single instruction for multiple data lanes [SIMD] · CPC title

• G06F9/3867

  using instruction pipelines · CPC title

• G06F9/3851

  from multiple instruction streams, e.g. multistreaming · CPC title