Preventing biological tissue adhesion

Patent metadata

Field	Value
Publication number	US-12377196-B2
Application number	US-202318167864-A
Country	US
Kind code	B2
Filing date	Feb 12, 2023
Priority date	Mar 18, 2016
Publication date	Aug 5, 2025
Grant date	Aug 5, 2025

Abstract

Methods and materials for mitigating biological tissue adhesion are described herein. One method for mitigating adhesion to a biological tissue includes administering an effective amount of a self-assembling peptide solution to the biological tissue, wherein the self-assembling peptide is between about 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.

First claim

What is claimed is:

1. A method for mitigating adhesion to a target area of a biological tissue or between biological tissues using a self-assembling peptide solution, the method comprising:
administering an effective amount of the self-assembling peptide solution to a biological tissue at a surgical site, wherein the self-assembling peptide comprises (RADA) 4 (SEQ ID NO:11);
wherein the self-assembling peptide is about 2.5% w/v of the solution;
wherein the self-assembling peptide solution forms a hydrogel under physiological conditions;
wherein the hydrogel mitigates adhesion to the biological tissue or of another biological tissue to the biological tissue at a surgical site;
wherein the hydrogel assists in healing of areas in which a surgical procedure was performed; and
wherein the biological tissue is cecum.

2. The method of claim 1 , wherein an effective amount of the self-assembling peptide solution is approximately 0.1 mL per 1 cm 2 to approximately 5 mL per 1 cm 2 of the target area.

3. The method of claim 2 , wherein the effective amount of the self-assembling peptide solution is approximately 1 mL per 1 cm 2 of target area.

4. The method of claim 1 , wherein the hydrogel is formed before administering the self-assembling peptide solution to the target area, or wherein the hydrogel is formed after administering the self-assembling peptide solution to said target area.

5. The method of claim 1 , wherein the self-assembling peptide solution further comprises a biologically active agent.

6. The method of claim 1 , wherein the self-assembling peptide solution is substantially free of cells and/or drugs.

7. The method of claim 1 , wherein the self-assembling peptide solution is administered in vivo.

8. The method of claim 1 , wherein the biological tissue is human tissue.

Assignees

• 3 D Matrix Ltd

Inventors

• Kobayashi Satoru
• Gil Eun Seok
• Spirio Lisa

Classifications

• A61L31/043

  Proteins; Polypeptides; Degradation products thereof · CPC title

• A61L31/145

  Hydrogels or hydrocolloids · CPC title

• A61B2017/00893

  pharmaceutically effective · CPC title

• A61B2017/00823

  Appendectomy · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title