Bladder perfusion pharmaceutical composition, preparation method therefor and application thereof
US-2024398841-A1 · Dec 5, 2024 · US
US12377070B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12377070-B2 |
| Application number | US-202017642184-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 11, 2020 |
| Priority date | Sep 12, 2019 |
| Publication date | Aug 5, 2025 |
| Grant date | Aug 5, 2025 |
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The present invention relates to novel heterocyclic compounds of general formula (I) their tautomers, stereoisomers, enantiomers, pharmaceutically acceptable salts and pharmaceutical composition. The compounds of general formula (I) belongs to the family of NOD like receptor family (NLR) protein NLRP3 modulators. The present invention thus relates to novel NLRP3 modulators and use of these novel inhibitor compounds in the treatment of disease or conditions as well as treatment of disease states mediated by NLRP3 as well as treatment of diseases or conditions in which interleukin 1β activity and interleukin-18 (IL-18) is implicated.
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We claim: 1. Compound(s) having structure of general formula (I) their tautomeric forms, their stereoisomers, their enantiomers, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them wherein, ‘A’ is selected from optionally substituted groups selected from (C 3 -C 8 )cycloalkyl, (C 6 -C 10 )aryl, heteroaryl, and heterocyclyl groups each…
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