Method for preparing monolithic coated surfaces

Patent metadata

Field	Value
Publication number	US-12372444-B2
Application number	US-202117545466-A
Country	US
Kind code	B2
Filing date	Dec 8, 2021
Priority date	Mar 15, 2018
Publication date	Jul 29, 2025
Grant date	Jul 29, 2025

Abstract

A carrier for adsorption a compound, comprising a support; and a shrink-fitted monolithic body attached to and surrounding at least a portion of the support. The monolithic body can be porous and configured to bind compounds in a solution either for the isolation or depletion of the compounds from the solution.

First claim

What is claimed is:

1. A method of determining the presence of a compound in a solution, which method comprises:
forming a carrier by:
inserting a support into a mold,
adding a monomer to the mold, and
polymerizing the monomer to form a shrink-fitted monolith adhered to the support, the shrink-fitted monolith adhered to the support being the carrier;

adding the solution to a container;
inserting the carrier into the container, wherein the shrink-fitted monolith of the carrier is in contact with the solution, the support of the carrier being inert to prevent reactions with the polymer or the solution; and
i) when the shrink-fitted monolith adsorbs the compound: adsorbing the compound to the shrink-fitted monolith; removing the shrink-fitted monolith from the solution in the container; providing the compound to a detector; and detecting and/or quantifying the amount of the compound in the solution based on an output of the detector; or
ii) when the shrink-fitted monolith does not adsorb the compound; adsorbing interfering compounds to the shrink-fitted monolith; removing the shrink-fitted monolith from the solution in the container; providing the solution to the detector; and detecting and/or quantifying the amount of the compound in the solution based on an output of the detector.

2. The method of claim 1 wherein the detector includes a liquid chromatography system.

3. The method of claim 1 wherein the liquid chromatography system includes an optical detector, a flame ionization detector, or any combination thereof.

4. The method of claim 1 wherein the detector includes a scintillation counter, an X-ray fluorescence detector, or any combination thereof.

5. The method of claim 1 wherein the detector includes a charged aerosol detector, a flame ionization detector, an aerosol-based detector, a flame photometric detector, an atomic-emission detector, a nitrogen phosphorus detector, an evaporative light scattering detector, an electrolytic conductivity detector, a MIRA detector, or any combination thereof.

6. The method of claim 1 wherein providing the compound to the detector includes providing the carrier and the adhered compound to the detector.

7. The method of claim 1 wherein providing the compound to the detector includes transferring the adhered compound from the carrier into the detector.

8. The method of claim 1 wherein the detector includes a mass spectrometer.

9. The method of claim 8 wherein the optical detector includes a UV detector, an IR detector, a visible light detector, a Raman detector, or any combination thereof.

10. The method of claim 1 wherein providing the compound to the detector includes removing the compound from the shrink-fitted monolith to the detector.

11. The method of claim 10 wherein removing the compound from the shrink-fitted monolith to the detector includes eluting the compound into a solution and providing the solution to the detector.

Assignees

• Dionex Corp

Inventors

• Pohl Christopher A
• Riviello John M

Classifications

• B01J20/3272

  Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds · CPC title

• B01J20/3291

  Characterised by the shape of the carrier, the coating or the obtained coated product · CPC title

• B01J20/3204

  Inorganic carriers, supports or substrates · CPC title

• B01J20/3282

  Crosslinked polymers · CPC title

• B01J20/321

  consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds · CPC title