Stabilized soluble pre-fusion RSV F polypeptides
US-10899800-B2 · Jan 26, 2021 · US
RSV virus-like particles and methods of use thereof
US12370252B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12370252-B2 |
| Application number | US-201917289827-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 29, 2019 |
| Priority date | Oct 29, 2018 |
| Publication date | Jul 29, 2025 |
| Grant date | Jul 29, 2025 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present disclosure relates to virus-like particles and vaccine compositions for inducing immunity and preventing respiratory syncytial virus (RSV) infection. Specifically, the disclosure provides virus like-particles (VLPs) for use in inducing immunity to respiratory syncytial virus (RSV) infections or symptoms thereof, wherein the VLP comprising a respiratory RSV matrix protein (M) and an RSV M2-1 protein, a glycoprotein (G), a fusion protein (F), and/or a phosphoprotein (P).
First claim
Opening claim text (preview).
What is claimed is: 1. A virus like particle (VLP) comprising a respiratory syncytial virus (RSV) M protein, an RSV P protein, an RSV F protein, and an RSV G protein, wherein the RSV F protein comprises SEQ ID NO: 23 or the RSV G protein comprises SEQ ID NO: 1. 2. The VLP of claim 1 , wherein the RSV F protein comprises SEQ ID NO: 23. 3. The VLP of claim 1 , wherein the RSV G protein comprises SEQ ID NO: 1. 4. The VLP of claim 1 , wherein the RSV G protein is a recombinant RSV G protein. 5. A vaccine comprising the VLP of claim 1 . 6. The vaccine of claim 5 , further comprising an adjuvant. 7. A method of inducing immunity to RSV infection or at least one symptom thereof in a subject, comprising administering one or more effective doses of the vaccine of claim 5 . 8. The method of claim 7 , wherein the one or more effective doses of the vaccine are administered to the subject via a route that is selected from the group consisting of an intramuscular route, a subcutaneous route, an intradermal route, an oral administration, a nasal administration, and inhalation.
Assignees
Inventors
Classifications
Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein · CPC title
Virus like particles [VLP] · CPC title
Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) · CPC title
characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title
from viruses · CPC title
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- What does patent US12370252B2 cover?
- The present disclosure relates to virus-like particles and vaccine compositions for inducing immunity and preventing respiratory syncytial virus (RSV) infection. Specifically, the disclosure provides virus like-particles (VLPs) for use in inducing immunity to respiratory syncytial virus (RSV) infections or symptoms thereof, wherein the VLP comprising a respiratory RSV matrix protein (M) and an …
- Who is the assignee on this patent?
- Univ Emory, Childrens Healthcare Of Atlanta, Wisconsin Alumni Res Found
- What technology area does this patent fall under?
- Primary CPC classification A61K39/155. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 29 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).