Immunomodulatory peptide

Patent metadata

Field	Value
Publication number	US-12365709-B2
Application number	US-202318364665-A
Country	US
Kind code	B2
Filing date	Aug 3, 2023
Priority date	Jan 12, 2017
Publication date	Jul 22, 2025
Grant date	Jul 22, 2025

Abstract

The present invention relates to an isolated peptide consisting of a sequence of 3 to 39 amino acids derived from the amino acid sequence SEQ ID NO: 1, said peptide having a sequence of amino acids selected from the group consisting of:
a) sequences of 3 to 39 amino acids comprising at least the residues 6 to 8 of SEQ ID NO: 1, and b) sequences of 3 to 39 amino acids having at least 70% identity with said sequence in a).

First claim

The invention claimed is:

1. An isolated peptide consisting of a sequence of amino acids selected from the group consisting of SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, and SEQ ID NO: 17,
wherein the peptide is amidated at the C-terminal and
wherein the peptide is a pro-inflammatory agent that increases expression of C-type lectin receptors on the surface of macrophages.

2. The isolated peptide according to claim 1 wherein the peptide is capable of being bound to the membrane of macrophages derived from monocytes.

3. A pharmaceutical composition, comprising:
the peptide according to claim 1
and
a pharmaceutically acceptable excipient.

4. The isolated peptide according to claim 1 , wherein the peptide has the amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6 and is amidated at the C-terminal.

5. The isolated peptide according to claim 1 , wherein the peptide has the amino acid sequence SEQ ID NO: 1 and is amidated at the C-terminal.

6. The isolated peptide according to claim 1 , wherein the peptide acylated at the N-terminal.

Assignees

• Institut National Univ Jean Francois Champollion
• Univ Toulouse Iii—Paul Sabatier
• Inst Nat Sante Rech Med
• Univ Rouen Normandie

Inventors

• Benmoussa Khaddouj
• Bonnafe Elsa
• Coste Agnès
• Leprince Jérôme
• Pipy Bernard
• Treilhou Michel

Classifications

• C07K7/08

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

• C07K7/06

  having 5 to 11 amino acids · CPC title

• C07K5/10

  Tetrapeptides · CPC title

• C07K5/08

  Tripeptides · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title