Filtration system for preparation of fluids for medical applications

Patent metadata

Field	Value
Publication number	US-12364795-B2
Application number	US-202318135255-A
Country	US
Kind code	B2
Filing date	Apr 17, 2023
Priority date	Apr 7, 2006
Publication date	Jul 22, 2025
Grant date	Jul 22, 2025

Abstract

A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.

First claim

The invention claimed is:

1. A system for filling multiple a plurality of containers, the system comprising:
a plurality of manifolds, each manifold having a manifold inlet and multiple manifold outlets;
a filter including a filter inlet port and multiple filter outlet ports, each of the multiple filter outlet ports being pre-attached to a respective manifold of the plurality of the manifolds through the manifold inlet of the respective manifold, and each of the multiple manifold outlets of the respective manifold being pre-attached to a respective container of the plurality of the containers by a respective filling line of each container of the plurality of the containers;
the plurality of the containers, each container of the plurality of the containers having an interior, each of the respective filling lines being connected to a respective interior; and
the respective filling lines, wherein all of the respective filling lines are fluidly sealed to the filter outlet ports, to manifold inlets, to the manifold outlets, and to the containers of the plurality of the containers, such that the interiors of the plurality of the containers are isolated from an external environment except the filter inlet port, via the filter, forming a combined interior volume which is sterile, an interior volume of the plurality of the manifolds being included in said combined interior volume.

2. The system according to claim 1 , further comprising:
a sterilizer that is configured to sterilize the filter and the combined interior volume together and concurrently.

3. The system according to claim 2 , further comprising:
a combined sealing and cutting mechanism that simultaneously cuts and seals each of the respective filling lines to isolate the plurality of containers after filling.

4. The system according to claim 1 , further comprising:
a concentrated medicament;
a metering pump or a flow meter; and
a controller that controls the metering pump or the flow meter to convey a predefined quantity of the concentrated medicament through the filter to each container of the plurality of containers.

5. The system according to claim 4 , further comprising:
a data carrier affixed to at least one of the plurality of containers, the data carrier storing data indicating properties of the concentrated medicament that has been injected into the container.

6. The system according to claim 5 , further comprising:
at least one sensor configured to measure a concentration level of the concentrated medicament filled into a particular one of the plurality of containers, wherein the controller records the measured concentration level or a value derived therefrom in the data carrier on the particular one of the plurality of containers.

7. The system according to claim 4 , further comprising:
a sensor configured to measure a fill condition and provide an output to the controller indicating the fill condition of one or more of said plurality of containers.

8. The system according to claim 7 , wherein the sensor includes a scale measuring weight of at least one of the plurality of containers.

9. The system according to claim 1 , further comprising:
a combined sealing and cutting mechanism that simultaneously cuts and seals the respective filling lines to isolate each of the plurality of containers after filling.

10. The system according to claim 1 , wherein
the multiple filter outlet ports are two filter outlet ports.

11. The system according to claim 1 , wherein
the filter includes the inlet filter port and a second filter inlet port.

12. The system according to claim 1 , wherein
the filter has a cylindrical shape.

13. The system according to claim 12 , wherein
the filter has two filter inlet ports and two filter outlet ports.

Assignees

• Nxstage Medical Inc

Inventors

• Burbank Jeffrey H
• Brugger James M

Classifications

• F16L55/07

  Arrangement or mounting of devices, e.g. valves, for venting or aerating or draining (apparatus for draining F16T) · CPC title

• B65B55/04

  Sterilising wrappers or receptacles prior to, or during, packaging {(sterilising bottles B67C7/00)} · CPC title

• B65B3/30

  by volumetric measurement · CPC title

• B65B3/28

  by weighing · CPC title

• B01L2300/0864

  comprising only one inlet and multiple receiving wells, e.g. for separation, splitting · CPC title