Hydrophilic coatings and methods of forming the same

Patent metadata

Field	Value
Publication number	US-12364789-B2
Application number	US-202318186654-A
Country	US
Kind code	B2
Filing date	Mar 20, 2023
Priority date	Apr 16, 2015
Publication date	Jul 22, 2025
Grant date	Jul 22, 2025

Abstract

A urinary catheter including a hydrophilic coatings on the outer surface of the catheter tube wherein the hydrophilic coatings comprises a hydrophilic polymer and a diacrylate compound have a number average molecular weight between about 200 and about 600.

First claim

The invention claimed is:

1. A urinary catheter, comprising:
a catheter tube having an outer surface, the catheter tube having a proximal end portion and a distal end portion;
a hydrophilic coating disposed on the outer surface of the catheter tube, the hydrophilic coating comprising polyvinylpyrrolidone and polyethylene glycol diacrylate having a number average molecular weight between about 200 and about 600; and
wherein hydrophilic coating comprises 94 wt % to 98 wt % polyvinylpyrrolidone and about 2 wt % to about 6 wt % polyethylene glycol diacrylate.

2. The urinary catheter of claim 1 , wherein when the hydrophilic coating is wetted with a wetting fluid, the hydrophilic coating has a coefficient of friction less than 0.05.

3. The urinary catheter of claim 1 , wherein the polyvinylpyrrolidone has a Mw of at least 500,000.

4. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate is a partially immiscible component of the hydrophilic coating.

5. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate comprises a discrete phase of the hydrophilic coating.

6. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate is phase separated from the polyvinylpyrrolidone.

7. The urinary catheter of claim 6 , wherein the hydrophilic coating comprises a phase separated morphology comprising a continuous phase of the polyvinylpyrrolidone and a discontinuous phase of the polyethylene glycol diacrylate.

8. The urinary catheter of claim 1 , wherein the hydrophilic coating further comprises a base coat layer disposed on the outer surface of the urinary catheter and a top coat layer disposed on the base coat layer wherein the top coat layer includes the polyethylene glycol diacrylate and polyvinylpyrrolidone.

9. The urinary catheter of claim 8 , wherein the base coat layer includes a diacrylate compound.

10. The urinary catheter of claim 9 , wherein the diacrylate compound of the base coat layer has a number average molecular weight of less than about 1000.

11. The urinary catheter of claim 9 , wherein the diacrylate compound of the base coat layer has a number average molecular weight of less than about 600.

12. The urinary catheter of claim 9 , wherein the diacrylate compound of the base coat layer has a number average molecular weight between about 200 and about 600.

13. The urinary catheter of claim 8 , wherein the base coat layer comprises a hydrophilic polymer.

14. The urinary catheter of claim 13 , wherein the hydrophilic polymer of the base coat layer comprises polyvinylpyrrolidone.

15. The urinary catheter of claim 8 , wherein the base coat layer comprises at least two immiscible or partially immiscible components.

16. The urinary catheter of claim 8 , wherein the base coat layer includes a polyethylene glycol diacrylate that comprises a discrete, continuous or bi-continuous phase within the hydrophilic coating.

17. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate is an immiscible component of the hydrophilic coating.

18. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate comprises continuous phase of the hydrophilic coating.

19. The urinary catheter of claim 1 , wherein the polyethylene glycol diacrylate comprises a bi-continuous phase of the hydrophilic coating.

Assignees

• Hollister Inc

Inventors

• O'Mahony John P
• Farrell David J

Classifications

• C08L2203/02

  for biomedical use · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title

• C08L39/06

  Homopolymers or copolymers of N-vinyl-pyrrolidones · CPC title

• A61L29/085 Primary

  Macromolecular materials · CPC title

• A61L2420/08

  Coatings comprising two or more layers · CPC title