Liquid feed pump and liquid chromatography device
US-11859600-B2 · Jan 2, 2024 · US
Method of controlling liquid chromatograph and liquid chromatograph
US12360087B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12360087-B2 |
| Application number | US-202118036950-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 7, 2021 |
| Priority date | Dec 24, 2020 |
| Publication date | Jul 15, 2025 |
| Grant date | Jul 15, 2025 |
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Abstract
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A method of controlling a liquid chromatograph that estimates the maximum value of the pressure reached during measurement before actually measuring a sample. The method includes a pump having a gradient function that feeds liquid while changing the composition of a plurality of eluents, according to gradient liquid feeding conditions, a sample filling unit for filling a sample, a separation column, an analysis flow channel connecting the pump to the separation column, and a pressure sensor which detects a pressure within the analysis flow channel during liquid feeding by the pump. A maximum pressure presumed during measurement is calculated based on an initial pressure as a pressure within the analysis flow channel when the pump starts feeding liquid and the gradient liquid feeding conditions and that when the maximum pressure presumed is determined to be a predetermined upper pressure limit, the sample filling is not performed.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of controlling a liquid chromatograph comprising: a pump having a gradient function capable of feeding liquid while changing composition of a plurality of eluents, according to gradient liquid feeding conditions; a sample filling unit for filling a sample; a separation column; an analysis flow channel which connects the pump to the separation column passing through the sample filling unit; and a pressure sensor which detects a pressure within the analysis flow channel during liquid feeding by the pump, wherein a maximum pressure presumed during measurement is calculated based on an initial pressure as a pressure within the analysis flow channel when the pump starts feeding liquid and the gradient liquid feeding conditions, and when the maximum pressure presumed is determined to be a predetermined upper limit of pressure and more, the sample filling is not performed. 2. The method of controlling the liquid chromatograph according to claim 1 , further comprising: two or more analysis flow channels each including the liquid feeding pump, the sample filling unit, and the separation column; and one or more detectors arranged downstream of the analysis flow channels, wherein when the maximum pressure presumed in one of the analysis flow channels is determined to be the upper limit of pressure and more, the sample filling is performed in the other analysis flow channel. 3. A liquid chromatograph comprising: a pump having a gradient function capable of feeding liquid while changing composition of a plurality of eluents, according to gradient liquid feeding conditions; a sample filling unit for filling a sample; a separation column; an analysis flow channel which connects the pump to the separation column passing through the sample filling unit; a pressure sensor which detects a pressure within the analysis flow channel during liquid feeding by the pump; and a control unit, wherein the control unit calculates a maximum pressure presumed during measurement, based on an initial pressure as a pressure within the analysis flow channel when the pump starts liquid feeding and the gradient liquid feeding conditions, and controls the sample filling unit not to perform the sample filling when the maximum pressure presumed is determined to be a predetermined upper limit of pressure and more. 4. The liquid chromatograph according to claim 3 , further comprising: two or more analysis flow channels each including a liquid feeding pump, the sample filling unit, and the separation column; and one or more detectors arranged downstream of the analysis flow channels, wherein when the maximum pressure presumed in one of the analysis flow channels is determined to be an upper limit of pressure and more, the sample filling unit is controlled to perform the sample filling in the other analysis flow channel.
Assignees
Inventors
Classifications
pumps · CPC title
Liquid chromatography · CPC title
Pressure or speed conditioning · CPC title
Optimising operation parameters · CPC title
- G01N30/32Primary
of pressure or speed (G01N30/36 takes precedence) · CPC title
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- What does patent US12360087B2 cover?
- A method of controlling a liquid chromatograph that estimates the maximum value of the pressure reached during measurement before actually measuring a sample. The method includes a pump having a gradient function that feeds liquid while changing the composition of a plurality of eluents, according to gradient liquid feeding conditions, a sample filling unit for filling a sample, a separation co…
- Who is the assignee on this patent?
- Hitachi High Tech Corp
- What technology area does this patent fall under?
- Primary CPC classification G01N30/32. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).