Properties and parameters of novel biodegradable metallic alloys

Patent metadata

Field	Value
Publication number	US-12359287-B2
Application number	US-202318099384-A
Country	US
Kind code	B2
Filing date	Jan 20, 2023
Priority date	Apr 12, 2017
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.

First claim

The invention claimed is:

1. A biodegradable medical implant device, comprising:
a metal alloy, consisting of:
from about 4.0-4.5 weight percent of zinc;
from about 0.3-0.5 weight percent of zirconium;
optionally, from about 0.25-1.0 weight percent of strontium;
optionally, from about 0.25-1.0 weight percent of cerium;
optionally, from about 1.0 to about 9.0 weight percent aluminum;
optionally, from about 0.1 to about 1.0 weight percent manganese;
optionally from about 0.25 to about 1.0 weight percent silver; and
a balance of magnesium including impurities, based on the total weight of the composition,

wherein the metal alloy has an average grain size from about 50 to about 100 μm, and wherein the metal alloy forms a primary phase of Mg (ZnZr), and an intermetallic secondary phase of Mg 7 Zn 3 precipitate is minimized or precluded in the metal alloy.

2. The device of claim 1 , wherein the zinc constitutes about 4.0 weight percent and the zirconium constitutes about 0.5 weight percent.

3. The device of claim 1 , wherein the zinc constitutes about 4.4 weight percent and the zirconium constitutes from about 0.3-0.4 weight percent.

4. The device of claim 1 , wherein strontium and/or cerium is present.

5. The device of claim 1 , wherein aluminum and/or manganese and/or silver is present.

6. The device of claim 1 , wherein the yield strength is 96 MPa or about 286.6 MPa and the ultimate tensile strength is 176 MPa or about 327.2 MPa.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Kumta Prashant N

Classifications

• C22C23/06 Primary

  with a rare earth metal as the next major constituent · CPC title

• A61L31/022

  Metals or alloys · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• C22C23/04

  with zinc or cadmium as the next major constituent · CPC title

• A61L27/047

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title