Diarylthiohydantoin compound as androgen receptor antagonist
US-2023035184-A1 · Feb 2, 2023 · US
Crystal of diarylthiohydantoin compound
US12358913B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12358913-B2 |
| Application number | US-202017427496-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 22, 2020 |
| Priority date | Feb 1, 2019 |
| Publication date | Jul 15, 2025 |
| Grant date | Jul 15, 2025 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present application belongs to the field of medicine, and in particular relates to a crystal of a diarylthiohydantoin compound, a preparation method therefor, and use thereof in the preparation of medicaments for treating related diseases which are androgen-mediated.
First claim
Opening claim text (preview).
The invention claimed is: 1. A crystal of a compound of formula I, wherein, in an X-ray powder diffraction pattern using Cu Kα radiation, diffraction peaks exist at 2θ of 13.47°±0.2°, 15.32°±0.2°, 15.98°±0.2°, 18.68°±0.2°, 23.11°±0.2° and 26.41°±0.2°. 2. The crystal of the compound of formula I according to claim 1 , wherein the crystal having an absorption peak at 238.92° C. according to differential scanning calorimetry analysis thereof 3. A crystalline composition, comprising no less than 50 wt % of the crystal of the compound of formula I according to claim 1 . 4. A pharmaceutical composition, comprising a therapeutically effective amount of the crystal of the compound of formula I according to claim 1 . 5. The crystal of the compound of formula I according to claim 1 , wherein, in an X-ray powder diffraction pattern using Cu Kα radiation, diffraction peaks exist at 2θ of 13.01°±0.2°, 13.47°±0.2°, 14.00°±0.2°, 15.32°±0.2°, 15.98°±0.2°, 18.68°±0.2°, 22.78°±0.2°, 23.11°±0.2°, 24.49°±0.2° and 26.41°±0.2°. 6. The crystalline composition according to claim 3 , comprising no less than 80 wt % of the crystal of the compound of formula I according to claim 1 . 7. The crystalline composition according to claim 6 , comprising no less than 90 wt % of the crystal of the compound of formula I according to claim 1 . 8. The crystalline composition according to claim 7 , comprising no less than 95 wt % of the crystal of the compound of formula I according to claim 1 . 9. The pharmaceutical composition according to claim 4 , comprising a pharmaceutically acceptable excipient.
Assignees
Inventors
Classifications
Crystalline forms, e.g. polymorphs · CPC title
Antineoplastic agents · CPC title
- A61K31/519Primary
ortho- or peri-condensed with heterocyclic rings · CPC title
- C07D471/04Primary
Ortho-condensed systems · CPC title
- A61K31/4184Primary
condensed with carbocyclic rings, e.g. benzimidazoles · CPC title
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- What does patent US12358913B2 cover?
- The present application belongs to the field of medicine, and in particular relates to a crystal of a diarylthiohydantoin compound, a preparation method therefor, and use thereof in the preparation of medicaments for treating related diseases which are androgen-mediated.
- Who is the assignee on this patent?
- Chia Tai Tianqing Pharmaceutical Group Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K31/519. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).