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Capsazepine analogs for the treatment of cancer and other proliferative diseases
US12358909B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12358909-B2 |
| Application number | US-201916563131-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 6, 2019 |
| Priority date | Aug 29, 2014 |
| Publication date | Jul 15, 2025 |
| Grant date | Jul 15, 2025 |
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- Title
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- Abstract
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Abstract
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The present disclosure relates generally to derivatives of capsazepine and methods of use thereof. In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases.
First claim
Opening claim text (preview).
What is claimed: 1. A method of treating oral squamous cell carcinoma, prostate cancer, colon cancer, pancreatic cancer, bladder cancer, cervical cancer, non-small cell lung cancer, breast cancer, glioma, glioblastoma or endometrial cancer comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the formula or a pharmaceutically acceptable salt, enantiomer or tautomer thereof. 2. The method according to claim 1 , wherein the cancer is an oral squamous cell carcinoma. 3. The method according to claim 1 , wherein the cancer is a solid tumor. 4. The method according to claim 3 , wherein the method comprises injecting the compound directly into the tumor. 5. The method according to claim 1 , wherein the method comprises administering the compound systemically. 6. The method according to claim 1 , wherein the method further comprises alleviating pain. 7. The method according to claim 1 , wherein the method further comprises administering a second therapeutic regimen to said patient. 8. The method according to claim 1 , wherein treating comprises reducing the size of a solid tumor. 9. The method according to claim 8 , wherein the compound reduces the tumor size such that the tumor becomes resectable.
Assignees
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Classifications
Iso-indoles; Hydrogenated iso-indoles · CPC title
having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings · CPC title
Antineoplastic agents · CPC title
the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
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Frequently asked questions
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- What does patent US12358909B2 cover?
- The present disclosure relates generally to derivatives of capsazepine and methods of use thereof. In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases.
- Who is the assignee on this patent?
- Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification C07D471/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).