Plunger rod and syringe assembly system and method

Patent metadata

Field	Value
Publication number	US-12357760-B2
Application number	US-202418416226-A
Country	US
Kind code	B2
Filing date	Jan 18, 2024
Priority date	Mar 28, 2017
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

A machine for coupling a plunger rod to a syringe assembly may include a carriage including a cradle having a seat portion sized to receive a syringe assembly and an aperture portion disposed above the seat portion and sized to receive a plunger rod. An actuating device may be operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly. The carriage may be selected from separate and interchangeable first and second carriages, wherein the first carriage includes a cradle adapted to receive a syringe assembly of a first size and the second carriage including a cradle sized to receive a syringe assembly of a second size that is different from the first size.

First claim

What is claimed:

1. A machine for coupling a plunger rod to a syringe assembly, the machine comprising:
a carriage having a movable cradle including a seat portion sized to receive the syringe assembly and an aperture portion disposed above the seat portion sized to receive the plunger rod;
an actuating device operatively coupled to the carriage and adapted to move the cradle from a first position to a second position to couple the plunger rod to the syringe assembly;
an elongated pressure plate positioned adjacent to the carriage and defining an inlet and an outlet, the inlet being sized to receive a proximal end of the plunger rod and apply a downward force on the proximal end of the plunger rod as the plunger rod moves from the inlet to the outlet; and
a constant tension spring coupled to the pressure plate, the constant tension spring providing a downward force to the pressure plate such that the downward force is transferred to the plunger rod via the pressure plate as the cradle moves between the first position and the second position.

2. The machine of claim 1 , wherein the inlet includes a ramped surface positioned above the outlet relative to the carriage.

3. The machine of claim 1 , further comprising:
at least one guide post, the pressure plate slidably coupled to the at least one guide post in a direction parallel to a longitudinal axis of the carriage; and
a threaded rod adjustably mounting the pressure plate relative to the carriage such that the pressure plate is adjustable in the direction parallel to the longitudinal axis of the carriage to accommodate plunger rods at different heights.

4. The machine of claim 1 , further comprising:
a friction element disposed adjacent to the carriage and below the pressure plate, the friction element adapted to engage a syringe barrel of the syringe assembly carried by the cradle as the cradle moves from the first position to the second position, the friction element adapted to apply a rotational force to the syringe barrel to spin the syringe assembly relative to the plunger rod; and
a guide plate and the friction element fixed to the guide plate, wherein the friction element is an elongated cord of an elastomeric material.

5. The machine of claim 1 , wherein the actuating device is operatively connected to the carriage and adapted to index the cradle between the first position and the second position in response to an activation event.

6. The machine of claim 1 , further comprising a movable plunger rod base coupled to the carriage, the plunger rod base disposed above the cradle and including an orifice sized to receive a flanged proximal end of the plunger rod, the orifice coaxially aligned with the aperture portion of the cradle, the plunger rod base being movable with the cradle from the first position to the second position;
a holding cap having an outwardly extending tab arranged to extend into the orifice of the plunger rod base, the holding cap removably attached to the plunger rod base; and
wherein the holding cap is fixed relative to the carriage and is disposed in the orifice when the cradle is in the first position.

7. The machine of claim 1 , wherein the cradle includes a cradle axis that is coaxial with longitudinal axes of the syringe assembly and plunger rod when the syringe assembly and plunger rod are disposed in the cradle, the cradle axis being disposed at an angle greater than zero degrees relative to vertical, and wherein the carriage comprises a rotational carousel with a rotational axis that is parallel to the cradle axis such that the rotational axis of the carriage is disposed at an angle greater than zero degrees relative to vertical.

8. The machine of claim 1 , wherein the carriage is rotationally disposed relative to the pressure plate.

9. The machine of claim 1 , wherein the actuating device includes a servomotor and an operation switch for operatively controlling the servomotor, the servomotor coupled to the carriage to move the cradle via the carriage.

10. The machine of claim 1 , wherein the actuating device includes a lever for a user to manually index the cradle from the first position to the second position, and
wherein the actuating device includes a slidable bracket arranged to move the lever.

11. The machine of claim 1 , wherein the seat portion of the cradle comprises a first roller and a second roller separated by a gap, the first and second rollers of the seat portion adapted to engage the syringe barrel of the syringe assembly and retain the syringe barrel in the gap when carried by the cradle, the first and second rollers allowing for the syringe assembly to spin as the cradle indexes from the first position to the second position,
wherein the carriage includes a plurality of cradles carried by the carriage.

12. The machine of claim 1 , further comprising an exit chute disposed adjacent to the carriage at the second position of the cradle, the exit chute adapted to receive the plunger rod and syringe assembly from the cradle after the plunger rod is coupled to the syringe assembly, and
wherein the exit chute includes a ramp, the ramp including a slot sized to receive the plunger rod and syringe assembly after the cradle moves to the second position.

Assignees

• Amgen Inc

Inventors

• Ketelaars Jeroen
• Leka Lawrence G
• Perez Ernesto J
• Rey Manuel
• Rivera Jomasoel
• Tapia Javier O
• Van Wezel Martin
• Vazquez Francisco Almedina
• Wah Reyes Noel

Classifications

• B23P21/00

  Machines for assembling a multiplicity of different parts to compose units, with or without preceding or subsequent working of such parts, e.g. with program control · CPC title

• B23P19/047

  for flexible profiles, e.g. sealing or decorating strips in grooves or on other profiles by devices moving along the flexible profile (hand tools therefor B25B27/0092) · CPC title

• A61M2207/10

  Device therefor · CPC title

• A61M5/31515 Primary

  Connection of piston with piston rod · CPC title

• A61M5/008

  Racks for supporting syringes or needles (A61M5/001 takes precedence) · CPC title