Flow balancing devices, methods, and systems

Patent metadata

Field	Value
Publication number	US-12357736-B2
Application number	US-202318107136-A
Country	US
Kind code	B2
Filing date	Feb 8, 2023
Priority date	Jul 18, 2016
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

First claim

The invention claimed is:

1. A method for controlling flow in a fluid circuit, comprising:
in a blood treatment system that regulates net ultrafiltration of a patient by balancing a fluid withdrawn from a blood treatment device against the fluid pumped into the blood treatment device by controlling a relative volume displaced during a treatment by an inflow pump and an outflow pump, wherein the inflow pump and the outflow pump are regulated independently of each other;
using a controller, during a testing mode, detecting a difference between a flow rate of the inflow pump and a flow rate of the outflow pump continuously over a test interval while storing difference data representing said difference over time;
using the controller, while detecting said difference and generating said difference data, controlling a pumping rate of at least one of the inflow and outflow pumps to minimize said difference in flow rate without establishing a minimum of said difference;
calculating, from the difference data and the pumping rate of the at least one of the inflow and outflow pumps, a control parameter for regulating said at least one of the inflow and outflow pumps by extrapolating from a trend in said difference data an equilibrium rate of the at least one of the inflow and outflow pumps that corresponds to the minimum of said difference; and
performing the treatment including controlling a net flow of the fluid to or from a patient by controlling the inflow and outflow pumps responsively to said control parameter.

2. The method of claim 1 , wherein the blood treatment system is a dialysis system.

3. The method of claim 1 , wherein the at least one of the inflow and outflow pumps pump fresh dialysate and spent dialysate, respectively.

4. The method of claim 1 , wherein the calculating includes calculating a time-resolved moving average from the difference data and fitting said time-resolved moving average to a curve of flow difference vs. time.

5. A system for controlling flow in a fluid circuit, comprising:
a blood treatment system that regulates net ultrafiltration of a patient by balancing a fluid withdrawn from a blood treatment device against the fluid pumped into the blood treatment device by controlling a relative volume displaced during a treatment by an inflow pump and an outflow pump, wherein the inflow pump and the outflow pump are regulated independently of each other;
a controller having a sensor adapted for indicating a difference between a flow rate of the inflow pump and the flow rate of the outflow pump;
the controller, during a testing mode, detecting the difference between the flow rates of the inflow and outflow pumps continuously over a test interval while storing difference data representing said difference over time;
the controller, while detecting said difference and generating said difference data, controlling a pumping rate of at least one of the inflow and outflow pumps to minimize said difference without establishing a minimum of said difference;
the controller calculating, from the difference data and the pumping rate of the at least one of the inflow and outflow pumps, a control parameter for regulating said at least one of the inflow and outflow pumps by extrapolating from a trend in said difference data an equilibrium rate of the at least one of the inflow and outflow pumps that corresponds to the minimum of said difference; and
the controller performing the treatment including controlling a net flow of the fluid to or from a patient by controlling the inflow and outflow pumps responsively to said control parameter.

6. The system of claim 5 , wherein the blood treatment system is a dialysis system.

7. The system of claim 5 , wherein the at least one of the inflow and outflow pumps pump fresh dialysate and spent dialysate, respectively.

8. The system of claim 5 , wherein the calculating includes calculating a time-resolved moving average from the difference data and fitting said time-resolved moving average to a curve of flow difference vs. time.

9. A blood treatment machine, comprising:
an inflow pump actuator;
an outflow pump actuator;
at least one pressure sensor connectable to a fluid circuit for measuring a pressure in the fluid circuit, the pressure sensor indicating a difference between a flow rate of the inflow pump actuator and a flow rate of the outflow pump actuator;
a controller that regulates the inflow and outflow pump actuators to achieve a selected net ultrafiltration of a patient by balancing a fluid withdrawn from a blood treatment device against the fluid pumped into the blood treatment device by independently regulating speeds of the inflow and outflow pump actuators to achieve a relative volume displaced during a treatment by the inflow and outflow pump actuators;
the controller, during a testing mode, detecting the difference between the flow rates of the inflow and outflow pumps continuously over a test interval while storing difference data representing said difference over time;
the controller, while detecting said difference and generating said difference data, controlling a pumping rate of at least one of the inflow and outflow pump actuators to minimize said difference without establishing a minimum of said difference;
the controller calculating, from the difference data and the pumping rate of the at least one of the inflow and outflow pump actuators, a control parameter for regulating said at least one of the inflow and outflow pump actuators by extrapolating from a trend in said difference data an equilibrium rate of the at least one of the inflow and outflow pump actuators that corresponds to a predetermined constant magnitude of the pressure indicated by said pressure sensor; and
the controller controlling a net flow of the fluid to or from a patient by controlling the inflow and outflow pumps responsively to said control parameter.

10. The blood treatment machine of claim 9 , wherein the blood treatment machine is a dialysis cycler.

11. The blood treatment machine of claim 9 , wherein the calculating includes calculating a time-resolved moving average from the difference data and fitting said time-resolved moving average to a curve of flow difference vs. time.

Assignees

• Nxstage Medical Inc

Inventors

• Desouza David
• Rubery Jr Daniel Joseph
• Treu Dennis M
• Wyeth Mark T
• James Jerome
• Casey Garrett D
• Brugger James M
• Schnell William J
• Burbank Jeffrey H
• Friederichs Goetz

Classifications

• A61M2205/3393

  by weighing the reservoir · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M1/3663

  Flow rate transducers; Flow integrators · CPC title

• A61M1/3607

  Regulation parameters · CPC title

• A61M1/1601 Primary

  Control or regulation · CPC title