Magnetoelectric nanocomposites and method of preparation thereof

Patent metadata

Field	Value
Publication number	US-12357583-B2
Application number	US-202217701110-A
Country	US
Kind code	B2
Filing date	Mar 22, 2022
Priority date	Mar 22, 2022
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

A magnetoelectric nanocomposite (MEN) is described. The MEN are used as a colorectal cancer treatment. The MEN includes a shell having at least one ferroelectric compound and a rare earth (R) metal doped spinel ferrite nanoparticle (SFNP) core, of a formula of Co x Mn 1-x R 2-y Fe y O z wherein x=0.1-0.9, y=1.90-1.99, and z=3-5; and R is at least one rare earth metal selected from the group consisting of cerium (Ce), europium (Eu), gadolinium (Gd), terbium (Tb) and thulium (Tm). A method of making MENs is also provided.

First claim

The invention claimed is:

1. A method of preferentially killing cancer cells, the method comprising:
contacting a magnetoelectric nanocomposite (MEN) and a cell culture comprising kidney (HEK)-293 cells or HCT-116 colorectal cancer cells, the MEN comprising:
a shell comprising barium titanate; and
a rare earth metal doped spinel ferrite nanoparticle (SFNP) core, having a formula of
Co 0.8 Mn 0.2 Eu 0.02 Fe 1.98 O 4 ,

wherein particles of the MEN have an average crystallite size of 41.25±0.05,
wherein upon the contacting with the MEN a higher percentage of the HCT-116 colorectal cancer cells are killed compared to the human embryonic kidney (HEK)-293, and
wherein, in the contacting, the cell culture of the HEK-293 cells or the HCT-116 colorectal cancer cells are contacted with the MEN in a range of from greater than 330 to less than 1410 g/mL for 48 hours.

2. The method of claim 1 , wherein the particles of the MEN have a substantially spherical shape with an average size in a range of from 5 to 30 nm, and
wherein the spheres are agglomerated to form aggregates with an average size in a range of from 50 to 500 nm.

3. The method of claim 2 , wherein the MEN comprises:
27-33 wt % Ba, 10-12 wt % Ti, 5-15 wt % Co, 3-6 wt % Mn, 0.5-1 wt % Eu, 21-25 wt % Fe, and 18-24 wt % O, based on the total weight of the Ba, Ti, Co, Mn, Eu, Fe, and O in the MEN.

4. The method of claim 3 , wherein the MEN hash:
a magnetoelectric coefficient of 14 mV/cm·Oe at 1800 Oe.

5. The method of claim 4 , having:
a zeta potential of −2.43 mV.

6. The method of claim 2 , wherein the aggregates form an agglomerated network.

7. The method of claim 1 , wherein the MEN consists of:
a shell comprising barium titanate; and
a rare earth metal doped spinel ferrite nanoparticle (SFNP) core, having a formula of Co 0.8 Mn 0.2 Eu 0.02 Fe 1.9 O 4 .

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Alfareed Tahani Mohammed
• Almessiere Munirah Abdullah
• Slimani Yassine
• Khan Firdos Alam
• Al-Suhaimi Ebtesam Abdullah
• Baykal Abdulhadi

Classifications

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K33/24

  Heavy metals; Compounds thereof · CPC title