Composition for treating or preventing skin pigmentation

Patent metadata

Field	Value
Publication number	US-12357560-B2
Application number	US-202318225377-A
Country	US
Kind code	B2
Filing date	Jul 24, 2023
Priority date	Nov 30, 2018
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

The present invention provides a composition for treating or preventing skin pigmentation, which contains fibroblasts as an active ingredient, wherein the fibroblasts are those fibroblasts which are less damaged than fibroblasts localized in a site where the skin pigmentation occurs, and the composition is characterized by being intended to be applied to a site where the pigmentation occurs or a dermis tissue around the site.

First claim

The invention claimed is:

1. A method for treatment of skin pigmentation of a subject in need thereof, the method comprising:
applying fibroblasts as an active ingredient to a site of skin pigmentation or a surrounding dermal tissue of the subject, wherein:
the fibroblasts are fibroblasts with less damage than fibroblasts localized at the site of skin pigmentation,
the fibroblasts have lower expression of a cell senescence marker than fibroblasts localized at the site of skin pigmentation,
the fibroblasts are derived from a tissue selected from the group consisting of a gluteal region, an abdominal region, a thorax, a femoral region, an upper arm, a dorsal region, a gingiva, an oral mucosa, a scalp, and an auricle rear,
the cell senescence marker is one or more selected from the group consisting of senescent acidic β-galactosidase (SA-βgal), cell cycle check mechanism-associated factor and cell senescence-associated secretory phenotype (SASP) factor, and
the skin pigmentation is caused by activated melanocytes induced by photo damaged-fibroblasts.

2. The method according to claim 1 , wherein the pigmentation is from one or more conditions selected from the group consisting of senile pigmentation spots, seborrheic keratosis, Chloasma, freckles and floriform pigmented spots.

3. The method according to claim 1 , wherein the fibroblasts are autologous fibroblasts.

4. The method of claim 1 , wherein the skin pigmentation is caused by overproduction of melanin by melanocytes due to ultraviolet ray exposure.

Assignees

• Shiseido Co Ltd

Inventors

• Koide Sayaka
• Takagi Masaya
• Yamada Shoko
• Ideta Ritsuro
• Satoh Takashi

Classifications

• A61Q19/02

  for chemically bleaching or whitening the skin · CPC title

• A61P17/00 Primary

  Drugs for dermatological disorders · CPC title

• A61K8/982

  Reproductive organs; Embryos, Eggs · CPC title

• A61K8/985 Primary

  Skin or skin outgrowth, e.g. hair, nails · CPC title

• A61K35/545

  Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells · CPC title