Articulating biocontainers

Patent metadata

Field	Value
Publication number	US-12357535-B2
Application number	US-202017639973-A
Country	US
Kind code	B2
Filing date	Sep 9, 2020
Priority date	Sep 10, 2019
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.

First claim

What is claimed:

1. A biocontainer, comprising:
a first film, the first film having an interior and exterior side;
articulating elements disposed on or within the first film, the articulating elements comprising a bowed path where a thickness of the first film remains unchanged across the bowed path or increase in proximity of the bowed path; and
a second film, optionally comprising articulating elements, joined to the first film to form the biocontainer having at least two walls and an inner volume defined by the at least two walls;
wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements,
wherein the first film is formed of one or more layers forming an inner contact zone, one or more layers of a gas impermeable zone, and one or more layers of polymers on an exterior side of the gas impermeable zone forming an outer strength zone,
wherein a substrate is incorporated into the first film between the inner contact zone and the gas impermeable zone, and the substrate is formed of a fibrous material, and
wherein the articulating elements are a double-jointed articulation that produces joints having flexibility in two directions, wherein combining the double-jointed articulation with patterns allow for folding in one direction and locking upon deployment in an opposite direction.

2. The biocontainer of claim 1 , wherein the substrate is formed of a material selected from the group consisting of woven and non-woven fibrous material.

3. The biocontainer of claim 2 , wherein the substrate has one or more openings formed in it to provide a device selected from the group of a viewing window, one or more ports for adding liquids, powders, processing aids, one or more ports for monitoring temperature, pH, conductivity, oxygen levels, carbon dioxide levels, foam height and other process variables, one or more ports for removing biological fluids, and/or one or more ports for housing sensors.

4. The biocontainer of claim 2 , wherein the substrate has one or more elongate openings formed in it to provide a viewing window into an interior of the biocontainer.

5. The biocontainer of claim 2 , wherein the substrate is formed of a material selected from the group consisting of polymers, metal fibers, carbon fibers and glass fibers.

6. The biocontainer of claim 1 , wherein the substrate is formed of a material selected from the group consisting of the fibrous material in a form selected from the group consisting of woven and non-woven materials and the fibrous material is made of a material selected from the group consisting of nylon, polyester, aramids, carbon, metal and polyolefins.

7. The biocontainer of claim 1 , wherein the second film is formed of a multilayered film.

8. The biocontainer of claim 1 , further comprising zones of articulation and zones of non-articulation to create articulated joints.

9. The biocontainer of claim 1 , wherein the biocontainer has a strength and/or rigidity capable of being a standalone biocontainer.

10. The biocontainer of claim 1 , wherein the biocontainer can maintain an expanded state without being supported by a secondary container or of a separate supporting structure, permitting a system having reduced footprint compared with supported systems.

11. The biocontainer of claim 1 , wherein the biocontainer has significantly greater flexural endurance, can be folded or compacted, expanded, folded or compacted, and expanded multiple times without failure.

12. The biocontainer of claim 1 , wherein the biocontainer comprises a 2-dimensional (2D) or a 3-dimensional (3D) biocontainer capable of storing biological fluids.

13. The biocontainer of claim 1 , wherein the biocontainer comprises a plurality of panels of film adhered to form a unitary structure.

14. The biocontainer of claim 1 , wherein a rigidity of the biocontainer is further enhanced by constructing stiffer non-articulated zones.

15. The biocontainer of claim 1 , wherein the articulating elements are created by thickening a cross section of the first film.

Assignees

• Emd Millipore Corp

Inventors

• Cleveland Shannon
• Varlamova Marina
• Saragosa John
• Decoste David
• Cacace Benjamin
• Lamothe Daniel
• Gagne George
• Dee James
• Moya Wilson
• Berti Perez Stefano

Classifications

• B65D25/54

  Inspection openings or windows · CPC title

• B65D2207/00

  Standing packages · CPC title

• B65D88/18

  bellows-shaped (B65D88/22 takes precedence) · CPC title

• B65D21/086

  Collapsible or telescopic containers (B65D1/0292 and B65D21/068 take precedence) · CPC title

• G01M3/3218

  for flexible or elastic containers · CPC title