Systems and methods for improving vision from an intraocular lens in an incorrect position and using refractive index writing

Patent metadata

Field	Value
Publication number	US-12357509-B2
Application number	US-202016837841-A
Country	US
Kind code	B2
Filing date	Apr 1, 2020
Priority date	Apr 5, 2019
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes determining a deviation in position of at least one optical element from a reference line corresponding to alignment of the apex of the cornea, center of the pupil, center of the IOL, and fovea, and/or determining a tilt of at least one of the optical elements relative to the reference line. The method can further include applying a plurality of focused laser pulses to a selected area of the implanted IOL to produce, through refractive index writing, a phase change pattern on the IOL that is configured to compensate for the deviation(s) and/or tilt to improve the foveal vision of the subject.

First claim

What is claimed is:

1. A system for improving vision of a subject, the system comprising:
at least one sensor configured to sense:
a tilt of at least one optical element relative to a reference line corresponding to alignment of the apex of the cornea, center of the pupil, center of an intraocular lens (IOL), and fovea, wherein the tilt produces an imperfection in foveal vision in the subject;

a control system operatively coupled to the at least one sensor and configured to:
receive data indicative of a photic phenomenon experienced by the subject;
receive associated sensed data corresponding to the tilt; calculate, based at least on the sensed data:
a multi-layered phase change pattern to produce on the IOL, that is configured to compensate for the tilt by induction of a left-right asymmetry in multiple layers that have a prismatic effect to improve the foveal vision of the subject;
a first pattern comprised of a first plurality of pulses of radiation to apply to the IOL to produce the phase change pattern;
one or more first selected areas of the IOL to which the first plurality of pulses are to be applied;
a second pattern comprising a second plurality of pulses of radiation to apply to the IOL to produce a radially dependent phase shift in the IOL to compensate for a phase delay of the IOL and the photic phenomenon; and
one or more second selected areas of the IOL to which the second plurality of pulses are to be applied; and

a pulsed radiation system operatively coupled to the control system and configured to, based on control by the control system, apply the first plurality of pulses of radiation to the IOL according to the first pattern to produce, by refractive index writing on the IOL, the phase change pattern on the IOL that is configured to compensate for the tilt to improve the foveal vision of the subject, and to apply the second plurality of pulses of radiation to the IOL according to the second pattern to produce the phase shift in the IOL to compensate for the phase delay and the photic phenomenon, wherein the control system is configured to determine the phase change pattern based at least in part on biometrics associated with corneal power.

2. The system of claim 1 , wherein the pulsed radiation system comprises a pulsed laser and is configured to apply the plurality of laser pulses to the one or more selected second areas of the IOL, according to the first pattern comprised of the plurality of pulses, to produce the phase change pattern.

3. The system of claim 1 , wherein the control system is configured to determine the phase change pattern based at least in part on biometrics associated with at least one of: IOL positioning; axial length; and refraction.

4. The system of claim 3 , wherein the biometrics associated with IOL positioning comprise measurements of at least one of effective lens position (ELP), tilt, and decentration of the IOL.

5. The system of claim 3 , wherein the biometrics associated with the corneal power comprise keratometry.

6. The system of claim 3 , wherein the biometrics associated with the corneal power comprise elevation maps.

7. The system of claim 1 , wherein the system is configured to determine the at least one of the tilt and a decentration using Purkinje imaging.

8. The system of claim 1 , further comprising an optical coherence tomography (OCT) system configured to determine the at least one of the tilt and decentration.

9. The system of claim 1 , wherein the system is configured to determine the phase change pattern using, at least in part, ray-tracing simulation.

10. The system of claim 1 , wherein the control system is configured to calculate the first pattern according to which the pulses of radiation are applied based at least in part on the at least one of a deviation in position and the tilt.

11. The system of claim 1 , wherein calculating the second pattern comprises:
measuring and mapping the photic phenomenon; and
determining the phase shift based on the measuring and mapping.

12. The system of claim 1 , wherein determining the phase shift comprises simulating one or more higher order aberrations based on a pupil size analysis of the subject.

13. The system of claim 1 , further comprising receiving feedback from the subject between the applications of the pulses of the second plurality of pulses and incorporating the feedback into subsequent applications of the pulses of the second plurality of pulses.

14. The system of claim 1 , further comprising:
determining higher order aberrations needed to be corrected to compensate for the photic phenomenon; and
correcting the higher order aberrations.

15. The system of claim 14 , wherein correcting the higher order aberrations comprises performing an iterative, closed-loop correction process to correct one or more of the higher order aberrations of the subject.

16. The system of claim 15 , wherein the closed-loop correction process includes measuring the higher order aberrations associated with the vision of the subject and determining, based at least in part on the measurements, a target higher order aberration correction that can be at least one of: full correction of at least one of the higher order aberrations of the subject; partial correction of at least one of the higher order aberration of the subject; and induction of at least one higher order aberration.

17. The system of claim 1 , wherein the IOL is multifocal, and further comprising producing the radially dependent phase shift in the IOL to render the IOL monofocal.

18. The system of claim 1 , further comprising eliminating a diffractive or a refractive design of the IOL in an outer part of the IOL, while maintaining the diffractive or the refractive design of the IOL in a central part of the IOL.

Assignees

• Amo Groningen Bv

Inventors

• Rosen Robert
• Gounou Franck Emmanuel
• Canovas Vidal Carmen
• Alarcon Heredia Aixa

Classifications

• A61F2009/00851

  Optical coherence topography [OCT] · CPC title

• A61F9/00827

  Refractive correction, e.g. lenticle · CPC title

• A61B3/117

  for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes · CPC title

• A61B3/102

  for optical coherence tomography [OCT] · CPC title

• A61F2009/00878

  Planning · CPC title