Method and system for monitoring heart function based on heart sound center of mass

Patent metadata

Field	Value
Publication number	US-12357235-B2
Application number	US-202217667172-A
Country	US
Kind code	B2
Filing date	Feb 8, 2022
Priority date	May 13, 2021
Publication date	Jul 15, 2025
Grant date	Jul 15, 2025

Abstract

A leadless implantable medical device (IMD) and method of using same are provided. The IMD comprises: a housing, a fixation element, electrodes configured to sense electrical cardiac activity (CA) signals over a period of time, an HS sensor configured to sense HS signals over the period of time, memory to store specific executable instructions, and one or more processors. The one or more processors and method: identify a characteristic of interest (COI) of a heartbeat from the CA signals, calculate a center of mass (COM) for at least one HS based on the HS signals to obtain a corresponding at least one HS COM, and calculate at least one of a therapy-related (TR) delay or a sensing-related (SR) blanking interval (BI) based on the at least one HS COM.

First claim

What is claimed is:

1. A leadless implantable medical device (IMD), comprising:
a housing;
a fixation element coupled to the housing and configured to secure the IMD in or proximate to a local chamber of the heart;
electrodes coupled to a sensing circuit provided on the housing and configured to sense electrical cardiac activity (CA) signals over a period of time;
a heart sound (HS) sensor configured to sense HS signals over the period of time;
memory to store specific executable instructions; and
one or more processors that, when executing the specific executable instructions, is configured to:
identify a characteristic of interest (COI) of a heartbeat from the CA signals;
calculate a center of mass (COM) for at least one HS based on the HS signals to obtain a corresponding at least one HS COM; and
calculate at least one of a therapy-related (TR) delay or a sensing-related (SR) blanking interval (BI) based on the at least one HS COM; and
deliver therapy or sense additional CA signals with the electrodes based on the at least one of the TR delay or the SR BI calculated based on the at least one HS COM.

2. The IMD of claim 1 , wherein the identify and calculate operations are performed in a calibration mode, and wherein, the calculate operations comprise:
calculate an S1 COM and an S2 COM;
calculate a diastolic interval (DI) based on the S1 COM and the S2 COM; and
calculate an AV delay by subtracting a delta value from the DI.

3. The IMD of claim 1 , wherein the one or more processors is further configured, when in a therapy mode, to collect and analyze HS signals to identify an HS of interest on a beat by beat basis.

4. The IMD of claim 3 , wherein the one or more processors is further configured, when in the therapy mode, to manage delivering of the therapy based on the HS of interest and the at least one of the TR delay or SR BI.

5. The IMD of claim 4 , wherein the one or more processors is further configured, in response to identifying the HS of interest, to start one or more event timers corresponding to the at least one of the TR delay or SR BI.

6. The IMD of claim 1 , wherein the IMD is configured to be implanted in or proximate to a ventricle, the at least one TR delay including an AV delay calculated by subtracting a delta value from a diastolic interval defined as the interval between an S1 COM and an S2 COM, the one or more processors is further configured to:
identify an S2 HS;
in response to the identifying the S2 HS, start an AV timer corresponding to the AV delay; and
deliver a ventricular therapy when an intrinsic ventricular event is not detected before the AV timer times out.

7. The IMD of claim 1 , wherein the at least one of the TR delay or SR BI is calculated by combining a delta value and at least one of a systolic interval, diastolic interval, S1-S1 interval, S2-S2 interval, S3-S3 interval, S4-S4 interval, S1-R-wave interval, S2-R-wave interval, S3-R-wave interval, or S4-R-wave interval.

8. The IMD of claim 1 , further comprising a sensor configured to obtain heart rate (HR) data, the one or more processors configured to store the HR data with the at least one of TR delay or the SR BI to associate a first HR with at least one of a first TR delay or first SR BI and to associate a second HR with at least one of a second TR delay or second SR BI.

9. A computer implemented method for monitoring heart function based on heart sounds (HS) in a leadless implantable medical device (IMD), the method comprising:
obtaining, with implantable electrodes coupled to sensing circuitry, electrical cardiac activity (CA) signals, sensed at the implantable electrodes provided on the leadless IMD, over a period of time;
obtaining HS signals, sensed by an implantable HS sensor, over the period of time;
under control of one or more processors,
identifying, with one or more processors of the leadless IMD, a characteristic of interest (COI) of a heartbeat from the CA signals;
calculating, with the one or more processors, a center of mass (COM) for at least one HS based on the HS signals to obtain a corresponding at least one HS COM;
calculating, with the one or more processors, at least one of a therapy-related (TR) delay or a sensing-related (SR) blanking interval (BI) based on the at least one HS COM; and
delivering therapy or sensing additional CA signals with the electrodes based on the at least one of the TR delay or the SR BI calculated based on the at least one HS COM.

10. The method of claim 9 , wherein the identifying and calculating operations are performed in a calibration mode, and wherein, the calculating operations comprise:
calculate an S1 COM and an S2 COM;
calculate a diastolic interval (DI) based on the S1 COM and the S2 COM; and
calculate an AV delay by subtracting a delta value from the DI.

11. The method of claim 9 , further comprising, when in a therapy mode, collecting and analyzing HS signals to identify an HS of interest on a beat by beat basis.

12. The method of claim 11 , further comprising, when in the therapy mode, managing delivering of therapy based on the HS of interest and the at least one of the TR delay or SR BI.

13. The method of claim 12 , further comprising, in response to identifying the HS of interest, starting one or more event timers corresponding to the at least one of the TR delay or SR BI.

14. The method of claim 9 , wherein the IMD is configured to be implanted in or proximate to a ventricle, the at least one TR delay including an AV delay calculated by subtracting a delta value from a diastolic interval defined as the interval between an S1 COM and an S2 COM, the method further comprising:
identifying an S2 HS;
in response to the identifying the S2 HS, starting an AV timer corresponding to the AV delay; and
delivering a ventricular therapy when an intrinsic ventricular event is not detected before the AV timer times out.

15. The method of claim 9 , wherein the at least one of the TR delay or SR BI is calculated by combining a delta value and at least one of a systolic interval, diastolic interval, S1-S1 interval, S2-S2 interval, S3-S3 interval, S4-S4 interval, S1-R-wave interval, S2-R-wave interval, S3-R-wave interval, or S4-R-wave interval.

Assignees

• Pacesetter Inc

Inventors

• Politis Nikolaos
• Mangual-Soto Jan O
• Richer Louis-Philippe
• Gill Jong
• Dawoud Fady

Classifications

• A61B5/4836

  Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence) · CPC title

• A61N1/37

  Monitoring; Protecting · CPC title

• A61N1/36592

  controlled by the heart rate variability · CPC title

• A61N1/3756

  Casings with electrodes thereon, e.g. leadless stimulators · CPC title

• A61B7/006

  Detecting skeletal, cartilage or muscle noise (A61B7/003 and A61B7/008 take precedence) · CPC title