Biodegradable bone glue

Patent metadata

Field	Value
Publication number	US-12350398-B2
Application number	US-202318139764-A
Country	US
Kind code	B2
Filing date	Apr 26, 2023
Priority date	Apr 28, 2017
Publication date	Jul 8, 2025
Grant date	Jul 8, 2025

Abstract

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

First claim

What is claimed is:

1. A method for filling void spaces within biological tissues comprising administering an amount of the composition comprising:
a bioresorbable polymer of Formula I, or a mixture thereof;
a solvent; and
a non-solvent
to the void spaces within biological tissues; and wherein Formula I is:

wherein:
R is:

2 TEA; or

wherein:
m is between 4 and 90;
n is between 5 and 200;
x is between 1 and 200; and
y is between 0 and 200.

2. A method for filling void spaces within biological tissues in oral cavities comprising administering an amount of a composition comprising:
a bioresorbable polymer of Formula I, or a mixture thereof;
a solvent; and
a non-solvent
to the void spaces within biological tissues in oral cavities; and wherein Formula I is:

wherein:
R is:

2 TEA; or

wherein:
m is between 4 and 90;
n is between 5 and 200;
x is between 1 and 200; and
y is between 0 and 200.

Assignees

• Evonik Operations Gmbh

Inventors

• Xue Teng
• Luppi Gianluigi
• Savietto Natalia Ruggeri
• Bowman Iii Howard K
• Spencer Paul Joseph
• Karau Andreas
• Zhang jian-feng
• Lizio Rosario
• Jones Marshall Scott

Classifications

• C08G63/6952

  derived from hydroxycarboxylic acids · CPC title

• C08G63/6922

  derived from hydroxy carboxylic acids · CPC title

• C08G63/6852 Primary

  derived from hydroxy carboxylic acids · CPC title

• B29L2031/753

  Medical equipment; Accessories therefor (bloodbags, medical bags B29L2031/7148; artificial eyes B29L2011/0008) · CPC title

• B29K2995/006

  Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible · CPC title