Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields

Patent metadata

Field	Value
Publication number	US-12343529-B2
Application number	US-202117210339-A
Country	US
Kind code	B2
Filing date	Mar 23, 2021
Priority date	Mar 31, 2020
Publication date	Jul 1, 2025
Grant date	Jul 1, 2025

Abstract

A method of assisting transducer placements on a subject's body for applying tumor treating fields includes: determining, based on one or more images associated with a portion of a subject's body, a first image data, wherein the first image data comprises one or more recommended transducer placement positions; determining, based on the one or more images, a second image data, wherein the second image data comprises one or more transducer placement positions; registering the second image data to the first image data; and generating a composite data comprising the one or more transducer placement positions and the one or more recommended transducer array placement positions.

First claim

What is claimed is:

1. A method of assisting transducer placements on a subject's body for applying tumor treating fields, the method comprising:
receiving one or more images of a portion of a subject's body;
determining, by one or more processors and based on the one or more images, a first image data, wherein the first image data comprises one or more pairs of transducer placement positions corresponding to locations of one or more pairs of transducers on the subject's body for applying tumor treating fields to the subject's body, wherein the first image data comprises two-dimensional (2D) image data;
determining, based on one or more medical images associated with the portion of the subject's body, a second image data, wherein the second image data comprises one or more recommended pairs of transducer placement positions, wherein the second image data comprises three-dimensional (3D) image data;
obtaining, by the one or more processors, a registered image data by registering the 2D image data of the first image data to the 3D image data of the second image data; and
generating a composite data based on the registered image data, the composite data comprising a 3D model that indicates the one or more pairs of transducer placement positions and the one or more recommended pairs of transducer placement positions.

2. The method of claim 1 , wherein the composite data comprises the one or more pairs of transducer placement positions overlaid on the one or more recommended pairs of transducer placement positions.

3. The method of claim 1 , further comprising:
displaying the composite data comprising the 3D model that indicates the one or more pairs of transducer placement positions and the one or more recommended pairs of transducer placement positions at a user device.

4. The method of claim 1 , wherein the one or more images comprise a plurality of video data, a plurality of images, an avatar, or a combination thereof.

5. The method of claim 1 , wherein registering the first image data to the second image data comprises:
determining one or more visual landmarks indicated by the first image data;
determining one or more visual landmarks indicated by the second image data; and
determining the one or more visual landmarks indicated by the first image data correspond to the one or more visual landmarks indicated by the second image data.

6. The method of claim 5 , wherein the one or more landmarks comprise at least one of anatomical landmarks or artificial landmarks.

7. The method of claim 6 , wherein the artificial landmarks comprise at least one of stickers, temporary tattoos, or design attributes of the one or more transducers.

8. The method of claim 1 , further comprising:
determining and outputting, based on the composite data, a variance of at least one of the one or more pairs of transducer placement positions from at least one of the one or more recommended pairs of transducer placement positions.

9. The method of claim 8 , further comprising:
sending a notification regarding the variance to a user device, wherein the notification comprises one or more instructions for correcting the variance.

10. The method of claim 1 , wherein the one or more pairs of transducer placement positions indicated by the first image data comprise one or more real-time placement positions for the one or more pairs of transducers.

11. The method of claim 1 , wherein the composite data is generated based on the registered image data and associated graphic guides, wherein the associated graphic guides comprise representations of one or more pairs of transducers based on a three-dimensional transducer map.

12. The method of claim 1 , wherein the one or more medical images associated with the portion of the subject's body are obtained using at least one of magnetic resonance imaging, x-ray computed tomography imaging, single-photon emission computed tomography imaging, positron emission tomography imaging.

13. The method of claim 1 , wherein the registering comprises transforming coordinates for one or more landmarks in the 2D image data to coordinates of the 3D image data.

14. The method of claim 1 , wherein the registering comprises using one of an affine transformation, a surface analysis, or a projection matrix to register the 2D image data of the first image data to the 3D image data of the second image data.

15. An apparatus of assisting transducer placements on a subject's body for applying tumor treating fields, the apparatus comprising:
one or more processors; and
a memory storing processor executable instructions that, when executed by the one or more processors, cause the apparatus to:
receive one or more images of a portion of a subject's body;
determine, by one or more processors and based on the one or more images, a first image data, wherein the first image data comprises one or more pairs of transducer placement positions corresponding to locations of one or more pairs of transducers on the subject's body for applying tumor treating fields to the subject's body, wherein the first image data comprises two-dimensional (2D) image data;
determine, based on one or more medical images associated with the portion of the subject's body, a second image data, wherein the second image data comprises one or more recommended pairs of transducer placement positions, wherein the second image data comprises three-dimensional (3D) image data;
obtain, by the one or more processors, a registered image data by registering the 2D image data of the first image data to the 3D image data of the second image data; and
generate a composite data based on the registered image data, the composite data comprising a 3D model that indicates the one or more pairs of transducer placement positions and the one or more recommended pairs of transducer placement positions.

16. The apparatus of claim 15 , wherein the processor executable instructions, when executed by the one or more processors, further cause the apparatus to display the composite data.

17. The apparatus of claim 15 , wherein the processor executable instructions that, when executed by the one or more processors, cause the apparatus to register the first image data to the second image data further cause the apparatus to:
determine one or more visual landmarks indicated by the first image data;
determine one or more visual landmarks indicated by the second image data; and
determine that the one or more visual landmarks indicated by the first image data correspond to the one or more visual landmarks indicated by the second image data.

18. The apparatus of claim 15 , wherein the composite data comprises a variance of at least one of the one or more pairs of transducer placement positions from at least one of the one or more recommended pairs of transducer placement positions indicated in the 3D model.

19. The apparatus of claim 18 , wherein the processor executable instructions, when executed by the one or more processors, further cause the apparatus to send a notification to a user device of the variance, wherein the notification comprises one or more instructions for correcting the variance.

Assignees

• Novocure Gmbh

Inventors

• Shamir Reuven Ruby
• Urman Noa
• Bomzon Zeev
• Bakalo Oren Ben Zion
• Glozman Yana

Classifications

• G16H40/67

  for remote operation · CPC title

• G06T17/00

  Three-dimensional [3D] modelling for computer graphics · CPC title

• G06T5/50

  using two or more images, e.g. averaging or subtraction · CPC title

• G06T2207/30096

  Tumor; Lesion · CPC title

• G06T2207/20221

  Image fusion; Image merging · CPC title