Compounds and methods for inhibiting fascin
US-9573946-B2 · Feb 21, 2017 · US
US12343349B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12343349-B2 |
| Application number | US-201917281084-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 22, 2019 |
| Priority date | Sep 28, 2018 |
| Publication date | Jul 1, 2025 |
| Grant date | Jul 1, 2025 |
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The present invention refers to Imipramine for use as inhibitor of fascin1 overexpression, preferably said overexpression of fascin1 is associated to cancer, and more preferably to colorectal cancer. It also refers to a method for the treatment of cancer mediated by fascin1 comprising administering to a subject in need thereof an effective amount of imipramine, and more preferably to colorectal cancer.
Opening claim text (preview).
The invention claimed is: 1. A method for the treatment of cancer mediated by fascin1 comprising administering to a subject in need thereof an effective amount of imipramine. 2. The method according to claim 1 , wherein the fascin1 is overexpressed. 3. The method according to claim 1 , wherein the cancer is colorectal cancer. 4. The method according to claim 3 , wherein the colorectal cancer is serrated adenocarcinoma. 5. The method according to claim 3 , wherein the colorectal cancer is selected from gastrointestinal stromal tumors, leiomyosarcomas or melanomas. 6. The method according to claim 3 , wherein the colorectal cancer is metastatic colorectal cancer.
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