Device for transferring a liquid from a first vial to a second vial

Patent metadata

Field	Value
Publication number	US-12343310-B2
Application number	US-202418440110-A
Country	US
Kind code	B2
Filing date	Feb 13, 2024
Priority date	Nov 2, 2017
Publication date	Jul 1, 2025
Grant date	Jul 1, 2025

Abstract

A device for transferring a liquid from a first vial to a second vial is disclosed having a dome portion configured to create an air flow when activated by compression and re-expansion, and a support body tightly supporting the dome portion to form a chamber with air therein. The support body includes first and second vial seats, and a transfer conduit. The first and second vial seats are arranged to receive the first and second vials. When the first and second vials are received in the first and second vial seats, the transfer conduit is arranged to establish a fluid connection between the first vial and the second vial. Upon activation of the dome portion, air is delivered into the first vial, thereby creating a pressure rise in the first vial which causes the liquid to transfer from the first vial to the second vial through the transfer conduit.

First claim

The invention claimed is:

1. A transfer device for transferring a liquid from a first vial to a second vial, comprising:
a resilient dome portion configured to create an air flow when activated by compression and re-expansion; and
a support body tightly supporting said dome portion to form a chamber comprising air for the air flow,
wherein the support body comprises a first vial seat, a second vial seat and a transfer conduit,
wherein the first vial seat of the support body is arranged to receive the first vial,
wherein the second vial seat of the support body is arranged to receive the second vial, and
wherein, when the first vial is received in the first vial seat and the second vial is received in the second vial seat,
the transfer conduit is arranged to establish a fluid connection between the first vial and the second vial, and
on activation of the dome portion, air is delivered into the first vial by the air flow, creating a pressure rise in the first vial which causes the liquid to transfer from the first vial to the second vial through the transfer conduit, and wherein the transfer device is configured so that
activation of the dome portion by compression of the dome portion causes air to be delivered into the first vial by the air flow, and
activation of the dome portion by re-expansion of the dome portion causes the liquid to be drawn from the first vial and to be delivered through the transfer conduit to the second vial.

2. The transfer device of claim 1 , wherein the transfer conduit comprises end sections each embodied as puncturing members protruding from the vial seats and arranged to establish flow pathways to and/or from an interior of the first vial through a pierceable cover of the first vial and to and/or from an interior of the second vial through a pierceable cover of the second vial.

3. The transfer device of claim 2 , wherein one of the puncturing members of the transfer conduit is arranged to end in, or adjacent to, the pierceable cover of the first vial, when the first vial is received in the first vial seat.

4. The transfer device of claim 1 , wherein the support body is arranged such that the first vial seat receives the first vial above the second vial seat receiving the second vial, when the dome portion is activated.

5. The transfer device of claim 1 , further configured so that re-expansion of the dome portion causes air to be drawn from the second vial and delivered to the chamber.

6. The transfer device of claim 1 , wherein an air-tight and liquid-tight separation wall is provided between the transfer conduit and the chamber.

7. The transfer device of claim 1 , comprising a first air duct configured to create an air flow pathway between an interior of the first vial and the chamber, when the first vial is received in the first vial seat.

8. The transfer device of claim 1 , further comprising a one-way valve arranged to allow air to be delivered from the chamber into the first vial and to prevent air to be delivered from the first vial into the chamber, when the first vial is received in the first vial seat.

9. The transfer device of claim 1 , further comprising a second air duct configured to create an air flow pathway between an interior of the second vial and the chamber, when the second vial is received in the second vial seat.

10. The transfer device of claim 1 , further comprising a one-way valve arranged to prevent air to be delivered from the chamber into the second vial and to allow air to be delivered from the second vial into the chamber, when the second vial is received in the second vial seat.

11. The transfer device of claim 9 , further comprising a first air duct configured to create an air flow pathway between an interior of the first vial and the chamber, when the first vial is received in the first vial seat, wherein the first air duct and the second air duct are aligned and positioned on opposite sides of the chamber.

12. The transfer device of claim 1 , wherein the transfer conduit connects the first vial, the second vial and the chamber, when the first vial is received in the first vial seat and second vial is received in the second vial seat, such that the first vial, the second vial and the chamber are in fluid communication.

13. The transfer device of claim 1 , wherein the transfer conduit directly connects the first vial and the second vial, when the first vial is received in the first vial seat and second vial is received in the second vial seat.

14. The transfer device of claim 1 , wherein the dome portion is made of a flexible elastomeric material.

15. The transfer device of claim 14 , wherein the flexible elastomeric material of the dome portion is silicone.

16. A transfer device system comprising a transfer device according to claim 1 , the first vial and the second vial.

17. The transfer device system of claim 16 , wherein said first vial comprises a liquid re-hydrating or diluent solution and/or a first liquid medicament component.

18. The transfer device system of claim 16 , wherein said second vial comprises a powdered agent and/or a second liquid medicament component or is initially empty.

Assignees

• Hoffmann La Roche

Inventors

• Gaillot Maxime
• Leah Roberta
• Reilly Declan
• Thueer Thomas
• Carroll Jack
• Coop James
• Sims Edward
• Teucher Mark

Classifications

• A61J1/2072

  for internal venting · CPC title

• A61J1/2051

  having tap means, e.g. tap means activated by sliding · CPC title

• A61J1/2013

  having two piercing ends · CPC title

• A61J1/2089 Primary

  Containers or vials which are to be joined to each other in order to mix their contents (combinations of vial and syringe for mixing their contents A61J1/2096) · CPC title

• A61J1/1406 Primary

  Septums, pierceable membranes · CPC title