Packaging for a pharmaceutical product

Patent metadata

Field	Value
Publication number	US-12343308-B2
Application number	US-202117907059-A
Country	US
Kind code	B2
Filing date	Feb 8, 2021
Priority date	Mar 27, 2020
Publication date	Jul 1, 2025
Grant date	Jul 1, 2025

Abstract

Packaging for a pharmaceutical product and a method of validating pharmaceuticals is disclosed. The packaging comprising a cavity; and validation circuitry comprising: a sensor adapted to output a signal in response to detecting a vapour in the cavity; and a detection circuit adapted to output an indication when the signal indicates a predefined vapour signature.

First claim

The invention claimed is:

1. A packaging for a pharmaceutical product comprising:
a cavity;
validation circuitry comprising:
a sensor adapted to output a signal in response to detecting a vapour in the cavity; and,
a detection circuit adapted to output an indication when the signal indicates a predefined vapour signature;

a bottle that contains the pharmaceutical product and that comprises a lid, where the lid comprises the validation circuitry, wherein:
the vapour is a marker vapour contained in the cavity and the cavity is a test cavity disposed in the lid comprising an inlet and an outlet;
the lid is adapted such that when in a first closed position, the test cavity is in fluid connection with an interior of the bottle and is sealed from an exterior of the bottle;
the lid is adapted such that when in a second closed position, the test cavity is sealed from the interior of the bottle and is in fluid connection with the exterior of the bottle; and
the lid is adapted such that when the lid is moved from the first closed position to the second closed position, the vapour is released from the test cavity.

2. The packaging of claim 1 , wherein the predefined vapour signature comprises at least one value stored in the validation circuitry and the detection circuitry is adapted to output the indication in dependence on a comparison based on the signal and the at least one stored value.

3. The packaging of claim 2 , wherein the detection circuitry comprises machine learning circuitry and the at least one stored value is generated and stored in a training procedure carried out by the machine learning circuitry.

4. The packaging of claim 1 , wherein the validation circuitry comprises flexible electronics.

5. The packaging of claim 1 , wherein the indication is a visual indication.

6. The packaging of claim 1 , wherein the detection circuit is adapted not to output the indication when the signal does not correspond to the predefined vapour signature.

7. The packaging of claim 1 , wherein the sensor comprises at least one of:
a thin film transistor sensor; and,
a resistive sensor.

8. The packaging of claim 1 , wherein the sensor comprises an array of sensors and the signal is comprised of a set of signals,
wherein each of the set of signals is output in response to the vapour; and,
the detection circuit is adapted to output the indication when the set of signals corresponds to the predefined vapour signature.

9. The packaging of claim 1 , wherein the vapour is an expiry vapour released from the pharmaceutical product; and,
a release rate of the expiry vapour from the pharmaceutical product is dependent on the age of the pharmaceutical product.

10. The packaging of claim 9 , wherein the predefined vapour signature comprises a minimum vapour concentration of the expiry vapour.

11. The packaging of claim 1 , wherein the vapour is a marker vapour contained in the cavity.

12. The packaging of claim 1 , wherein the cavity is adapted to release the vapour in response to the cavity being breached.

13. The packaging of claim 1 , wherein the vapour is an expiry vapour released from the pharmaceutical product, and a release rate of the expiry vapour from the pharmaceutical product is dependent on the age of the pharmaceutical product,
wherein the lid of the bottle comprises a lock mechanism having an unlocked state and a locked state; and,
wherein the lock mechanism is adapted to enter the locked state in response to the indication.

14. The packaging of claim 1 , wherein the pharmaceutical product is separated from the marker vapour by a removable layer.

15. The packaging of claim 1 , wherein the bottle is adapted to release the marker vapour from the cavity in response to the lid being opened.

16. The packaging of claim 1 , wherein the bottle comprises a test spot adapted to release the marker vapour from the cavity in response to the cavity being breached.

17. The packaging of claim 1 , wherein the validation circuitry comprises a power source.

18. The packaging of claim 17 , wherein the power source is a printed power source.

19. The packaging of claim 18 , wherein the printed power source is a printed battery.

20. The packaging of claim 18 , wherein the printed power source is an energy harvester.

21. A system comprising:
the packaging of claim 1 ; and,
a vapour gun containing a preselected test vapour, wherein the vapour gun is adapted to output a quantity of the preselected test vapour in response to a user stimulus,
wherein the detection circuitry is adapted to output the indication when the signal indicates the preselected test vapour is in the cavity.

22. The system of claim 21 , wherein the vapour gun further comprises a plurality of test vapours comprising the preselected test vapour and is adapted to output one of the plurality of test vapours in response to a user selection.

23. The system of claim 22 , wherein the plurality of test vapours comprises the predefined vapour signature.

24. A method of validating pharmaceuticals comprising:
generating a signal in response to sensing a vapour in a cavity of packaging for a pharmaceutical product using a sensor; and,
indicating when the signal indicates a predefined vapour signature, wherein:
the packaging comprises a bottle that contains the pharmaceutical product and the bottle comprises a lid and the lid comprises the sensor,
the vapour is a marker vapour contained in the cavity,
the cavity is a test cavity disposed in the lid comprising an inlet and an outlet,
moving the lid to a first closed position causes the test cavity to be in fluid connection with an interior of the bottle and sealed from an exterior of the bottle,
moving the lid to a second closed position causes the test cavity to be sealed from the interior of the bottle and in fluid connection with the exterior of the bottle, and
moving the lid from the first closed position to the second closed position causes the vapour to be released from the test cavity.

25. Packaging for a pharmaceutical product comprising:
means for generating a signal in response to sensing a vapour in a cavity of packaging for a pharmaceutical product using a means for sensing; and
means for indicating when the signal indicates a predefined vapour signature, wherein:
the packaging comprises a bottle that contains the pharmaceutical product,
the bottle comprises a lid and the lid comprises the means for sensing,
the vapour is a marker vapour contained in the cavity, and the cavity is a test cavity disposed in the lid comprising an inlet and an outlet,
the lid is adapted such that when in a first closed position, the test cavity is in fluid connection with an interior of the bottle and is sealed from an exterior of the bottle,
the lid is adapted such that when in a second closed position, the test cavity is sealed from the interior of the bottle and is in fluid connection with the exterior of the bottle, and
the lid is adapted such that when the lid is moved from the first closed position to the second closed position, the vapour is released from the test cavity.

Assignees

• Advanced Risc Mach Ltd

Inventors

• Özer Emre

Classifications

• G01M3/02

  by using fluid or vacuum · CPC title

• B65D81/2076

  in an at least partially rigid container · CPC title

• B65D79/02

  Arrangements or devices for indicating incorrect storage or transport ({B65D79/005 takes precedence } ; measuring devices G01) · CPC title

• B65D51/248

  the closure being provided with transient audible or visual signaling means, e.g. for indicating dispensing, or other illuminating or acoustic devices, e.g. whistles (B65D55/026, B65D55/028 take precedence; for indicating incorrect storage B65D79/02) · CPC title

• A61J2200/70

  Device provided with specific sensor or indicating means · CPC title