Method for locomotion of a nanorobot and implementations thereof

Patent metadata

Field	Value
Publication number	US-12336779-B2
Application number	US-202017631735-A
Country	US
Kind code	B2
Filing date	Jul 31, 2020
Priority date	Aug 1, 2019
Publication date	Jun 24, 2025
Grant date	Jun 24, 2025

Abstract

The present disclosure relates to a method for locomotion of at least one nanorobot through a biochemical environment. The present disclosure also reveals a method for locomotion of nanorobots for use in drug delivery, delivery of materials for medical imaging and medical diagnosis.

First claim

We claim:

1. A method for locomotion of at least one nanorobot through a biochemical environment, the method comprising:
(a) introducing the at least one nanorobot in the biochemical environment;
(b) inducing propulsion in the at least one nanorobot in the biochemical environment by applying a magnetic field of a strength in the range of 80-160 G; and
(c) heating a localized environment around the at least one nanorobot in the biochemical environment to induce deadhesion and locomotion to the at least one nanorobot,
wherein the heating the localized environment is carried out by a process selected from IR heating, magnetic hyperthermia carried out by application of a magnetic field having a strength in the range of 1×10 3 to 3×10 4 G oscillating at a frequency of 10 to 500 kHz, eddy current heating, radio frequency heating, or combinations thereof.

2. The method as claimed in claim 1 , wherein the heating is localized to a radius of 1-10 μm around the at least one nanorobot in the biochemical environment.

3. The method as claimed in claim 1 , wherein heating the localized environment around the at least one nanorobot in the biochemical environment enhances porosity to induce locomotion to the at least one nanorobot.

4. The method as claimed in claim 3 , wherein the enhancement in porosity is in the range of 10-20%.

5. The method as claimed in claim 1 , wherein the application of a magnetic field is selected from at least one of a homogenous magnetic field, a time-varying magnetic field, a magnetic field that changes its direction, a magnetic field that rotates, a magnetic field that contains a gradient, or combinations thereof.

6. The method as claimed in claim 1 , wherein the biochemical environment is an environment comprising collagen, gelatin, hydrogels, extracellular matrix, fibrillar protein, and combinations thereof.

7. The method as claimed in claim 6 , wherein the biochemical environment has a reynolds number less than 1.

8. The method as claimed in claim 6 , wherein the biochemical environment has a viscosity in the range of 0.5 cP-1×10 6 cP.

9. The method as claimed in claim 1 , wherein the at least one nanorobot has an inner hull to carry a cargo of actives like anti-cancer drugs, radioactive agent for imaging, radioisotopes for radiotherapy and drugs for chemotherapy.

10. The method as claimed in claim 1 , wherein the method is used for delivery of the drug molecules.

11. The method as claimed in claim 1 , wherein the method is used as a contrast agent in medical imaging.

12. The method as claimed in claim 1 , wherein the method is used to deliver materials that aid medical diagnosis.

13. The method as claimed in claim 1 , wherein the method is used to deliver material that have therapeutic value.

Assignees

• Indian Inst Scient

Inventors

• Ghosh Ambarish
• Dasgupta Debayan

Classifications

• H01F10/14

  containing iron or nickel ({H01F10/126} , H01F10/13, H01F10/16 take precedence) · CPC title

• A61B2017/00345

  Micromachines, nanomachines, microsystems · CPC title

• A61B34/73

  Manipulators for magnetic surgery · CPC title

• H01F41/20

  by evaporation · CPC title

• A61B2017/00411

  actuated by application of energy from an energy source outside the body · CPC title