Method and apparatus for selective treatment of biological tissue

Patent metadata

Field	Value
Publication number	US-12336756-B2
Application number	US-202318519731-A
Country	US
Kind code	B2
Filing date	Nov 27, 2023
Priority date	Dec 23, 2016
Publication date	Jun 24, 2025
Grant date	Jun 24, 2025

Abstract

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

First claim

What is claimed is:

1. An apparatus for selectively affecting a pigmented region in a layer of a skin tissue, comprising:
a radiation arrangement including at least one laser configured to emit at least one electromagnetic radiation (EMR) beam;
an optical arrangement including at least one lens configured to direct and focus the at least one EMR beam as a convergent beam into at least one focal region within a dermis layer of the skin tissue containing at least one pigmented region and at least one unpigmented region;
a sensor configured to detect at least one of a velocity or a position of the apparatus over the surface of the skin tissue, and provide signals which are based on the detected speed to affect at least one property of the at least one EMR beam; and
a controller configured to (a) receive the signals from the sensor and (b) control at least one of the radiation arrangement or the optical arrangement so as to scan the at least one EMR beam over a treatment area of the skin tissue within the dermis layer to:
(i) generate a plasma locally at the at least one pigmented region of the tissue when the at least one focal region overlaps with the at least one pigmented region, and
(ii) avoid generation of the plasma at the at least one unpigmented region when the at least one focal region does not overlap with the at least one pigmented region and overlaps with the at least one unpigmented region.

2. The apparatus according to claim 1 , wherein the at least one focal region has a width less than 100 μm within the dermal layer.

3. The apparatus according to claim 2 , wherein the controller is further configured to control a power output of the radiation arrangement so as to provide a particular fluence of the at least one EMR beam in the at least one focal region when the signals indicate that the apparatus is in motion over the surface of the skin tissue.

4. The apparatus of claim 1 , wherein the optical arrangement comprises a plurality of lenses.

5. The apparatus of claim 1 , wherein a scan speed of the at least one EMR beam is between 5 mm/s to 5 cm/s.

6. The apparatus of claim 5 , wherein a width of each one of the plurality of lenses is between 1 mm and 3 mm.

7. The apparatus of claim 6 , wherein at least two of the plurality of lenses have different focal lengths.

8. The apparatus of claim 1 , wherein the controller is further configured to avoid generation of the plasma when the signals from the sensor indicate that the apparatus is stationary relative to the skin tissue.

Assignees

• Massachusetts Gen Hospital
• Blossom Innovations Llc

Inventors

• Anderson Richard Rox
• Manstein Dieter
• Chan Henry Hin Lee
• Zuo Vincent

Classifications

• A61B2018/00696

  Controlled or regulated parameters · CPC title

• A61B2018/00642

  with feedback, i.e. closed loop control · CPC title

• A61B2018/00452

  Skin · CPC title

• A61B2018/20553

  with special lens or reflector arrangement · CPC title

• A61B2018/00708

  switching the power on or off · CPC title