Synchronization of ion generation with cycling of a discontinuous atmospheric interface

Patent metadata

Field	Value
Publication number	US-12334328-B2
Application number	US-202318209074-A
Country	US
Kind code	B2
Filing date	Jun 13, 2023
Priority date	Jan 20, 2011
Publication date	Jun 17, 2025
Grant date	Jun 17, 2025

Abstract

The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

First claim

What is claimed is:

1. A method for monitoring a reaction in real-time, the method comprising:
providing an online reaction monitoring system that comprises a reaction vessel that comprises an outlet port; a channel that extends from within the outlet port; an electrode operably associated with a distal end of the channel; and a mass spectrometer;
selecting a solvent that is compatible as both a reaction solvent and an ionization solvent;
conducting a reaction in the solvent in the reaction vessel;
flowing a portion of the solvent from the reaction vessel through the channel;
generating ions of one or more analytes in the solvent by applying an electrical potential to a distal end of the channel via the electrode;
using the flowed portion of the solvent from the vessel as the ionization solvent; and
analyzing the ions in the mass spectrometer, thereby monitoring the reaction in real-time.

2. The method according to claim 1 , wherein the electrode is positioned to inductively interact with a distal end of the channel.

3. The system according to claim 1 , wherein the system further comprises a gas source operably coupled to the reaction vessel through one of the one or more inlet ports.

4. The system according to claim 1 , wherein the channel extends into the reaction vessel.

5. The system according to claim 1 , wherein the channel comprises one or more splitters, wherein a first splitter withdraws a portion of a liquid from the channel, and a second splitter is coupled to a nebulizing gas source in order to introduce a nebulizing gas into the channel.

6. The method according to claim 1 , wherein both positive and negative ions are produced.

7. The method according to claim 6 , further comprising recording mass spectra of the positive and negative ions.

8. The method according to claim 7 , wherein recording comprises switching polarity of a mass spectrometer while the mass spectrometer is receiving the sample.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Li Guangtao
• Huang Guangming
• Duncan Jason
• Li Xin
• Sokol Ewa
• Yan Xin

Classifications

• H01J49/4205

  Device types · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• G01N27/62 Primary

  by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode · CPC title

• H01J49/045

  with means for using a nebulising gas, i.e. pneumatically assisted · CPC title

• H01J49/0018

  Microminiaturised spectrometers, e.g. chip-integrated devices, Micro-Electro-Mechanical Systems [MEMS] · CPC title