Systems and methods for isolating a target ion in an ion trap

Patent metadata

Field	Value
Publication number	US-12334322-B2
Application number	US-202217833337-A
Country	US
Kind code	B2
Filing date	Jun 6, 2022
Priority date	Apr 13, 2016
Publication date	Jun 17, 2025
Grant date	Jun 17, 2025

Abstract

The invention generally relates to systems and methods for isolating a target ion in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap.

First claim

What is claimed is:

1. A system, the system comprising:
a mass spectrometer comprising an ion trap; and
a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a dual frequency waveform to the ion trap that ejects non-target ions from the ion trap while retaining a target ion in the ion trap, wherein the dual frequency waveform consists of a combination of two linear resonances, wherein a first of the two linear resonances is chosen to eject the non-target ions lower in mass than the target ion and a second of the two linear resonances is chosen to eject the non-target ions higher in mass than the target ion, wherein the two linear resonances are applied over a plurality of time points.

2. The system according to claim 1 , wherein the CPU is further caused to apply a third frequency along with the dual frequency waveform in order to isolate a second target ion.

3. The system according to claim 1 , wherein the dual frequency waveform comprises first and second frequencies that are applied simultaneously.

4. The system according to claim 1 , wherein the dual frequency waveform comprises first and second frequencies that are applied sequentially.

5. The system according to claim 1 , wherein a first frequency of the dual frequency waveform is higher than a secular frequency of the target ion.

6. The system according to claim 5 , wherein the first frequency is accessible by low alternating current (AC) amplitudes.

7. The system according to claim 6 , wherein more frequencies of motion are accessed upon increasing the AC amplitude.

8. The system according to claim 5 , wherein a second frequency of the dual frequency waveform is lower than a secular frequency of the target ion.

9. The system according to claim 8 , wherein the second frequency is accessible by low alternating current (AC) amplitudes.

10. The system according to claim 9 , wherein more frequencies of motion are accessed upon increasing the AC amplitude.

11. A system, the system comprising:
a mass spectrometer comprising an ion trap; and
a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to:
apply a dual frequency waveform to the ion trap, wherein the dual frequency waveform consists of a combination of two linear resonances in which:
a first frequency of the dual frequency waveform that is applied to the ion trap is higher than a secular frequency of a target ion in the ion trap; and
a second frequency of the dual frequency waveform that is applied to the ion trap is lower than the secular frequency of the target ion in the ion trap;
wherein the two linear resonances are applied over a plurality of time points.

12. The system according to claim 11 , wherein the first and second frequency of the dual frequency waveforms are applied simultaneously to the ion trap.

13. The system according to claim 11 , wherein the first and second frequency waveforms are sinusoidal waveforms.

14. The system according to claim 11 , wherein the first frequency of the dual frequency waveform is accessible by low alternating current (AC) amplitudes.

15. The system according to claim 14 , wherein more frequencies of motion are accessed upon increasing the AC amplitude.

16. The system according to claim 11 , wherein the second frequency of the dual frequency waveform is accessible by low alternating current (AC) amplitudes.

17. The system according to claim 16 , wherein more frequencies of motion are accessed upon increasing the AC amplitude.

18. The system according to claim 11 , wherein the mass spectrometer is a miniature mass spectrometer.

19. The system according to claim 11 , wherein the ion trap is a quadrupole ion trap.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Snyder Dalton

Classifications

• H01J49/426

  Methods for controlling ions · CPC title

• H01J49/42 Primary

  Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons · CPC title

• H01J49/0031 Primary

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title