Methods and devices for aseptic dry transfer

Patent metadata

Field	Value
Publication number	US-12331275-B2
Application number	US-202318143239-A
Country	US
Kind code	B2
Filing date	May 4, 2023
Priority date	Nov 30, 2017
Publication date	Jun 17, 2025
Grant date	Jun 17, 2025

Abstract

Devices and systems for product transfer, such as a dissolvable microcarriers, are described. In one example, the product delivery device may include an inlet port; a conical section that may include a wide end and a narrow end; an outlet port flush with the narrow end of the conical section and extending away from the conical section; and a securement feature configured to connect the wide end of the conical section to a container. In another example, a system for aseptic dry product delivery may include a container at least partially filled with the aseptic dry product; a product delivery device; a pressure source connected to an inlet port; and a receiving vessel where the aseptic dry product is collected.

First claim

What is claimed is:

1. A system for product delivery, comprising:
a container; and
a product delivery device comprising:
a three-piece cap comprising:
a first piece comprising:
an inlet port;
a conical section with a wide end and a narrow end;
an outlet port flush with the narrow end of the conical section,

a second piece comprising a securement feature configured to connect the wide end of the conical section to the container; and
a third piece comprising a gasket, the gasket including an internal angle based at least in part on an angle of the conical section;

wherein the first piece engages with the second piece to deform the gasket when connected to the container, and wherein the container is configured to transfer product from the conical section through the outlet port.

2. The system of claim 1 , further comprising a dip tube connected to the inlet port and extending into the container to a side opposite the inlet port.

3. The system of claim 1 , wherein the gasket is configured to deform to create a hermetic seal.

4. The system of claim 1 , wherein the container further comprises a product, the product comprising a dry free flowing powder.

5. The system of claim 4 , wherein the product comprises dissolvable microcarriers.

6. A system for aseptic dry product delivery, comprising:
a container comprising an aseptic dry product;
a product delivery device including:
a three-piece cap, the three-piece cap comprising:
a first piece comprising:
an inlet port;
a conical section with a wide end and a narrow end; and
an outlet port disposed flush with the narrow end of the conical section;

a second piece comprising a securement feature configured to couple the wide end of the conical section to a container; and
a third piece comprising a gasket, the gasket including an internal angle based at least in part on an angle of the conical section,

wherein the first piece engages with the second piece to deform the gasket when connected to the container;
a pressure source connected to the inlet port; and
a receiving vessel configured to receive the aseptic dry product;
wherein the container is configured to transfer the aseptic dry product from the conical section through the outlet port.

7. The system of claim 6 , wherein the gasket is configured to deform to create a hermetic seal within the system.

8. The system of claim 6 , wherein the system is closed to the environment.

9. The system of claim 6 , wherein a dip tube connected to the inlet port extends into the container, and wherein the dip tube is configured to transfer pressure from the pressure source into the container.

10. The system of claim 6 , wherein the inlet port comprises an external barb and the outlet port comprises an external barb.

11. The system of claim 6 , further comprising:
a first tube connected to the inlet port;
a first clamp configured to pinch the first tube;
a second tube connected to the outlet port; and
a second clamp configured to pinch the second tube.

12. The system of claim 11 , wherein the container is at least partially filled with the aseptic dry product, the dry product comprising dissolvable microcarriers.

13. The system of claim 12 , wherein the receiving vessel is configured to hydrate the dry dissolvable microcarriers.

Assignees

• Corning Inc

Inventors

• Russell Ryann Loren
• Seeto Paul Kevin

Classifications

• B65D83/06

  for dispensing powdered or granular material · CPC title

• B65D41/16

  Snap-on caps or cap-like covers · CPC title

• B65D41/04

  Threaded or like caps or cap-like covers secured by rotation · CPC title

• B65D41/00

  Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper (clamping or other pressure-applying devices for securing or retaining closure members B65D45/00) · CPC title

• B65D39/00

  Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers (lids or covers B65D43/00) · CPC title