Method and system for biventricular or left ventricular pacing

Patent metadata

Field	Value
Publication number	US-12324919-B2
Application number	US-202117552773-A
Country	US
Kind code	B2
Filing date	Dec 16, 2021
Priority date	Sep 11, 2018
Publication date	Jun 10, 2025
Grant date	Jun 10, 2025

Abstract

Systems and methods are provided for detecting arrhythmias in cardiac activity is provided. The systems and methods include measuring conduction delays between an atria (A) and multiple left ventricular (LV) electrodes to obtain multiple intrinsic A/LV intervals, measuring conduction delays between a right ventricular (RV) and the multiple LV electrodes to obtain multiple intrinsic VV intervals. The systems and methods include calculating a first atrial ventricular (AV) delay based on at least one of the intrinsic A/LV intervals, and calculating a second AV delay based on at least one of the intrinsic VV intervals. The systems and methods include selecting a biventricular (BiV) pacing mode or an LV only pacing mode based on a relation between the first and second AV delays, and delivering a pacing therapy based on the selecting operation.

First claim

What is claimed is:

1. A computer implemented method for detecting arrhythmias in cardiac activity, comprising:
under control of one or more processors configured with specific executable instructions,
measuring conduction delays between an atria (A) sensing site at an A electrode and each of multiple distinct left ventricular (LV) sensing sites at corresponding multiple LV electrodes to obtain corresponding multiple intrinsic A/LV intervals;
measuring conduction delays between a right ventricular (RV) sensing site at an RV electrode and each of the multiple LV sensing sites at the corresponding multiple LV electrodes to obtain corresponding multiple intrinsic VV intervals;
calculating a first atrial ventricular (AV) delay based on at least one of the intrinsic A/LV intervals;
calculating a second AV delay based on at least one of the intrinsic VV intervals;
selecting between i) a biventricular (BiV) pacing mode and ii) an LV only pacing mode based on a relation between the first and second AV delays; and
delivering a pacing therapy, utilizing a selected one of the BiV pacing mode or LV only pacing mode, based on the selecting operation.

2. The method of claim 1 , further comprising:
selecting between the first AV delay and the second AV delay based on whether the relation between the first and second AV delays indicates conduction block on a right or left side of the heart; wherein the delivering further comprises delivering the pacing therapy utilizing the one of the first AV delay and the second AV delay selected.

3. The method of claim 1 , wherein the selecting further comprises selecting one of the first and second AV delays to be utilized for the pacing therapy based on whether the relation between the first and second AV delays satisfy a criteria, wherein the pacing therapy is delivered based on the one of the first and second AV delays that is selected.

4. The method of claim 1 , further comprising calculating a percentage relation between the first and second AV delays AVD 1 and comparing the percentage relation to a criteria, the selecting operation comprising selecting between the BiV pacing mode and the LV only pacing mode based on whether the percentage relation satisfies the criteria, the selecting operation comprising selecting between the first and second AV delays based on whether the percentage relation satisfies the criteria, wherein the pacing therapy is delivered based on the one of the first and second AV delays that is selected.

5. The method of claim 1 , wherein, during the LV only pacing mode, the RV is not paced regardless of a conduction delay between the atria and the RV.

6. The method of claim 1 , further comprising measuring a conduction delay between atria and the RV to obtain an intrinsic A/RV interval, wherein the calculating the second AV delay is based on a difference between the intrinsic A/RV interval and a lowest one of the intrinsic VV intervals.

7. The method of claim 1 , wherein the calculating the second AV delay further comprises determining a lowest one of the intrinsic VV intervals; and wherein the calculating the first AV delay further comprises determining a lowest one of the intrinsic A/LV intervals.

8. The method of claim 1 , the delivering the pacing therapy further comprising timing delivery of pacing pulses in the BiV pacing mode in a fusion timing manner with intrinsic conduction in at least one of the RV and LV, the pacing therapy utilizing the first AV delay, the first AV delay corresponding to a minimum one of the multiple intrinsic A/LV intervals.

9. The method of claim 1 , the delivering the pacing therapy further comprising timing delivery of pacing pulses in the LV only pacing mode in a fusion timing manner with intrinsic conduction from the RV apex along the LV, the pacing therapy utilizing the second AV delay, the second AV delay corresponding to a minimum one of the multiple intrinsic VV intervals.

10. The method of claim 1 , wherein the measuring the intrinsic VV intervals further comprises delivering a paced event at each of the LV electrodes and measuring an associated conduction time to an RV electrode.

11. The method of claim 1 , wherein the selecting operation includes selecting between i) the BiV pacing mode and ii) the LV only pacing mode based on whether the relation between the first and second AV delays indicates conduction block on a right or left side of the heart.

12. The method of claim 1 , further comprising selecting a lowest one of the intrinsic A/LV intervals and a lowest one of the intrinsic VV intervals for calculating the first and second AV delays.

13. The method of claim 1 , further comprising:
providing a lead with the multiple LV electrodes configured to be located proximate to the LV with the multiple LV electrodes located at the corresponding LV sensing sites;
providing an implantable medical device (IMD) coupled to the lead, the IMD including the one or more processors for:
sensing cardiac activity at the A, LV and RV sensing sites;
utilizing the cardiac activity for measuring the conduction delays; and
performing the measuring, calculating, selecting and delivering operations.

14. A computer implemented method for detecting arrhythmias in cardiac activity, comprising:
under control of one or more processors configured with specific executable instructions,
measuring a conduction delay between an atria (A) sensing site at an A electrode and a left ventricular (LV) sensing site at an LV electrode to obtain an intrinsic A/LV interval;
measuring a conduction delay between a right ventricular (RV) sensing site at an RV electrode and the LV sensing site to obtain an intrinsic VV interval;
calculating first and second atrial ventricular (AV) delays based on the intrinsic A/LV interval and the intrinsic VV interval;
determining whether a relation between the first and second AV delays indicates conduction block on a right side or a left side of the heart;
selecting between i) a biventricular (BiV) pacing mode and ii) an LV only pacing mode based on whether the relation indicates conduction block on the right side or the left side of the heart; and
delivering a pacing therapy, utilizing a selected one of the BiV pacing mode or LV only pacing mode, based on the selecting operation.

15. The method of claim 14 , the method further comprising:
providing a lead with multiple LV electrodes configured to be located proximate to the LV with the multiple LV electrodes located at corresponding multiple LV sensing sites;
providing an implantable medical device (IMD) coupled to the lead, the IMD including the one or more processors for:
sensing cardiac activity at the A, LV and RV sensing sites;
the measuring operations further comprising:
measuring conduction delays, based on the cardiac activity, between the A sensing site and each of the multiple LV sensing sites to obtain corresponding multiple intrinsic A/LV intervals; and
measuring conduction delays, based on the cardiac activity, between the RV sensing site and each of the multiple LV sensing sites to obtain corresponding multiple intrinsic VV intervals.

16. The method of claim 15 , further comprising selecting a lowest one of the intrinsic A/LV intervals and a lowest one of the intrinsic VV intervals for calculating the first and second AV delays.

17. The method of claim 14 , further comprising delivering the pacing therapy utilizing the first or second AV delay based on whether the relation between the first and second AV delays indicates conduction block on the right or left side of the heart.

18.

Assignees

• Pacesetter Inc

Inventors

• Mangual-Soto Jan O
• Badie Nima
• Mcspadden Luke C
• Gill Jong
• Richer Louis-Philippe

Classifications

• A61N1/3684

  for stimulating the heart at multiple sites of the ventricle or the atrium · CPC title

• A61N1/3688

  configured for switching the pacing mode, e.g. from AAI to DDD · CPC title

• A61N1/025

  Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors · CPC title

• A61N1/3686

  configured for selecting the electrode configuration on a lead (A61N1/3688 takes precedence) · CPC title

• A61N1/36592

  controlled by the heart rate variability · CPC title