Conjugates of a factor viii moiety having an oxime-containing linkage
US-2021369817-A1 · Dec 2, 2021 · US
Conjugates of a factor VIII moiety having an oxime-containing linkage
US12324828B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12324828-B2 |
| Application number | US-202318114710-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 27, 2023 |
| Priority date | Jul 22, 2016 |
| Publication date | Jun 10, 2025 |
| Grant date | Jun 10, 2025 |
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- Title
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Abstract
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The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.
First claim
Opening claim text (preview).
It is claimed: 1. A polymeric oxyamine reagent having a structure selected from: where X is-NH(CH 2 ) 1-6 NHC(O)CH 2 —, and each (n) ranges from about 1 to about 4,000. 2. The polymeric oxyamine reagent of claim 1 , wherein X is —NH(CH 2 ) 2 NHC(O)CH 2 —. 3. The polymeric oxamine reagent of claim 1 , wherein each (n) is about 227. 4. The polymeric oxamine reagent of claim 1 , wherein each (n) is selected such that the weight average molecular weight of the branched poly(ethylene glycol) polymer ranges from greater than 5,000 Daltons to 100,000 Daltons.
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Classifications
having oxygen in addition to nitrogen · CPC title
acyclic · CPC title
acyclic · CPC title
acyclic · CPC title
cyclic · CPC title
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- What does patent US12324828B2 cover?
- The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, among other things.
- Who is the assignee on this patent?
- Nektar Therapeutics
- What technology area does this patent fall under?
- Primary CPC classification A61K47/60. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).