Porous membrane sensor assembly

Patent metadata

Field	Value
Publication number	US-12320745-B2
Application number	US-202017756375-A
Country	US
Kind code	B2
Filing date	Dec 21, 2020
Priority date	Dec 19, 2019
Publication date	Jun 3, 2025
Grant date	Jun 3, 2025

Abstract

The present invention relates a sensor assembly for analyzing a complex fluid sample. The sensor assembly comprises a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet for fluid handling in the sample chamber. The sample chamber comprises a first sample space and a second sample space. The second sample space comprises a porous membrane sensor element for detecting an analyte in a continuous fraction of the complex fluid sample. The porous membrane sensor element comprises a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising pores extending from respective openings at the sensor surface into the porous membrane. The pores are configured with regard to the analyte for diffusive fluid communication with the second sample space. The sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space.

First claim

The invention claimed is:

1. A sensor assembly for analyzing a complex fluid sample, the sensor assembly comprising:
a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a direction of flow from the inlet towards the outlet in the sample chamber;
wherein the sample chamber comprises a first sample space and a second sample space,
the second sample space comprising a porous membrane sensor element for detecting an analyte; the porous membrane sensor element comprising a porous membrane with a front side defining a sensor surface for contacting the fluid sample, the sensor surface facing towards the second sample space, the porous membrane comprising dead end pores extending from respective openings at the sensor surface into the porous membrane, wherein the pores are configured with regard to the analyte for diffusive fluid communication with the second sample space,
wherein the sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space, between the first sample space and the second sample space, wherein the flow-perturbing element is configured to stir the complex fluid sample at the second sample space.

2. The sensor assembly according to claim 1 , wherein the porous membrane sensor element is configured for detecting a high molecular weight analyte.

3. The sensor assembly according to claim 1 , wherein the first sample space comprises one or more further sensor elements for detecting respective further analytes.

4. The sensor assembly according to claim 1 , wherein the flow-perturbing element is formed as a connection nozzle connecting a feed channel of the second sample space to a downstream end of the first sample space.

5. The sensor assembly according to claim 1 , wherein the flow-perturbing element is formed as a connection nozzle arranged at an angle with respect to a principal axis of a sample channel forming the first sample space, wherein the angle is at least 30 degrees with respect to said principal axis.

6. The sensor assembly according to claim 1 , wherein the flow-perturbing element is located upstream of the second sample space at a distance from an entry orifice of the second sample space of at least 0.3 mm and/or up to 3 mm.

7. The sensor assembly according to claim 1 , wherein the sensor surface is planar.

8. The sensor assembly according to claim 1 , wherein the sensor surface is arranged parallel to the direction of flow from the inlet to the outlet in the second sample space of the sample chamber.

9. The sensor assembly according to claim 1 , wherein the second sample space has a cylindrical shape defined by a top wall, a bottom wall opposite to the top wall, and a circumferential wall connecting the top and bottom wall; wherein a feed orifice is arranged at an upstream end of the second sample space; wherein a discharge orifice is arranged at a downstream end thereof; and wherein the porous membrane sensor element is arranged in the top wall of the second sample space.

10. The sensor assembly according to claim 9 , wherein the feed and discharge orifices are arranged in the circumferential wall opposite to each other.

11. The sensor assembly according to claim 9 , wherein a height of the second sample space as seen in a direction from the top wall to the bottom wall is less than one half of a transverse dimension of the second sample space.

12. The sensor assembly according to claim 9 , wherein the bottom wall is curved to reduce the distance of the bottom wall from the top wall in a center portion of the second sample space, as compared to a peripheral portion thereof.

13. The sensor assembly according to claim 1 , wherein the porous membrane sensor element is configured for detecting the analyte by optical probing.

14. The sensor assembly according to claim 1 , wherein the porous membrane is a translucent membrane.

15. The sensor assembly according to claim 14 , wherein the porous membrane sensor element further comprises a reflective layer arranged at the front side of the translucent membrane.

16. The sensor assembly according to claim 13 , wherein the porous membrane is a translucent membrane, wherein the porous membrane sensor element further comprises
an optical input port connected to a back side of the translucent membrane, the back side facing away from the front side, optical input port being adapted for feeding probing light to a probing region of the translucent membrane through the back side; and
an optical output port connected to the back side of the translucent membrane, the optical output port being adapted for collecting an optical response from the translucent membrane through the back side.

17. The sensor assembly according to claim 1 , wherein the flow-perturbing element is located upstream of the second sample space at a distance from an entry orifice of the second sample space of at least 1 mm.

18. The sensor assembly according to claim 1 , wherein the flow-perturbing element is located upstream of the second sample space at a distance from an entry orifice of the second sample space of up to 10 mm.

19. A sensor assembly for analyzing a complex fluid sample, the sensor assembly comprising:
a sample chamber for holding the complex fluid sample, the sample chamber being defined by chamber walls and having an inlet and an outlet defining a flow path from the inlet to the outlet in the sample chamber;
wherein the sample chamber comprises a first sample space and a second sample space,
the second sample space comprising a porous membrane sensor element for detecting an analyte, the porous membrane sensor element being positioned within the flow path,
wherein the sample chamber further comprises a flow-perturbing element arranged upstream of the second sample space.

Assignees

• Radiometer Medical Aps

Inventors

• Kjaer Thomas
• Andersen Willy Lindegaard

Classifications

• G01N2021/773

  Porous polymer jacket; Polymer matrix with indicator · CPC title

• G01N2021/7763

  Sample through flow · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• G01N2201/0627

  Use of several LED's for spectral resolution · CPC title

• G01N21/31 Primary

  Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry {(G01N21/72 takes precedence)} · CPC title