Medical device having space for assisting in embedding of bio sample in embedding material

Patent metadata

Field	Value
Publication number	US-12319905-B2
Application number	US-202017438858-A
Country	US
Kind code	B2
Filing date	Mar 12, 2020
Priority date	Mar 15, 2019
Publication date	Jun 3, 2025
Grant date	Jun 3, 2025

Abstract

It was difficult to create a thin bio sample embedded in an embedding material without using an expensive microtome. The present invention provides a medical device having a space for assisting in the embedding of a bio sample in an embedding material, the medical device being provided with a cover part and a base part having a recessed section in which the space is created by covering the cover part, wherein the base part is provided with a flow passage having an inlet section that is in fluid communication with the space, and the flow passage is configured such that when a force is applied to the medical device so that the volume of the space decreases, the embedding material flows out while preventing a positional misalignment of the bio sample inside the embedding material.

First claim

What is claimed is:

1. A medical device having a space for assisting in embedding of a biological sample in an embedding material, the medical device comprising:
a lid, and
a base with a recessed part where the space is defined by covering the recessed part with the lid,
wherein the base comprises:
a flow channel having inlets in fluid communication with the space,
a spacer being in contact with the lid; and
a spacer support being in contact with the spacer,
the flow channel comprises at least four main channels,
each main channel independent of each other,
each inlet of the at least four main channels is arranged apart from each other at equal angles to a center of a bottom of the recessed part,
the flow channel is configured to allow the embedding material to flow out while preventing misalignment of the biological sample within the embedding material when a force is applied to the medical device to reduce the volume of the space, and
one of the following (1) and (2) is satisfied:
(1) at least a part of a surface of the spacer support being in contact with the spacer comprises grooves, and the flow channel is defined by covering the grooves with the spacer; and
(2) at least a part of a surface of the spacer being in contact with the spacer support comprises grooves, and the flow channel is defined by covering the grooves with the spacer support.

2. The medical device according to claim 1 , wherein the flow channel comprises one or more sub-channels in each region between two adjacent main channels of the at least four main channels, and
each region comprises the same number of sub-channels.

3. The medical device according to claim 1 , wherein
the spacer comprises a through hole.

4. The medical device according to claim 1 , wherein the spacer is made of an elastic material.

5. The medical device according to claim 1 , wherein the spacer support is made of a material with high thermal conductivity.

6. The medical device according to claim 1 , further comprising a holder,
wherein the holder is a hollow body comprising a straight body and an overhang extending toward a center of the holder at an end of the straight body,
an inner diameter of the straight body is larger than outer diameters of the base and lid, and
an inner diameter of the overhang is smaller than the outer diameter of the lid.

Assignees

• Univ Tohoku

Inventors

• Tanaka Yuji

Classifications

• A61K35/545

  Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells · CPC title

• A61K35/30

  Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue · CPC title

• A61F2/14

  Eye parts, e.g. lenses or corneal implants; Artificial eyes · CPC title

• A61P27/02

  Ophthalmic agents · CPC title

• A61F9/0017

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title