Macromolecular compositions comprising indene-derivatives, preparation thereof, and use thereof

Patent metadata

Field	Value
Publication number	US-12318756-B2
Application number	US-202318167109-A
Country	US
Kind code	B2
Filing date	Feb 10, 2023
Priority date	Dec 4, 2017
Publication date	Jun 3, 2025
Grant date	Jun 3, 2025

Abstract

The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.

First claim

The invention claimed is:

1. A ninhydrin-type sorbent, wherein the sorbent has a urea binding capacity of more than 2.3 mmol urea per gram of sorbent, wherein the sorbent is a macromolecular composition that is a polymer, and comprises ninhydrin-type moieties, wherein ninhydrin-type moieties are 4-[2,2-dihydroxy-1H-indene-1,3(2H)]-dionyl, 5-[2,2-dihydroxy-1H-indene-1,3(2H)]-dionyl, 6-[2,2-dihydroxy-1H-indene-1,3(2H)]-dionyl, or 7-[2,2-dihydroxy-1H-indene-1,3(2H)]-dionyl.

2. The ninhydrin-type sorbent according to claim 1 , wherein the sorbent has a urea binding capacity of more than 2.4 mmol urea per gram of sorbent.

3. The ninhydrin-type sorbent according to claim 1 , wherein the sorbent has a urea binding capacity of more than 2.6 mmol urea per gram of sorbent.

4. The ninhydrin-type sorbent according to claim 1 , wherein the polymer comprises at least one of the following monomers:

5. The ninhydrin-type sorbent according to claim 1 , wherein the polymer comprises a comonomer.

6. The ninhydrin-type sorbent according to claim 5 , wherein the comonomer is selected from the group consisting of styrene, isopropenylbenzene, divinylbenzene, vinylbenzenesulfonic acid, acrylic acid, methacrylic acid, methyl acrylate, methyl methacrylate, 2-hydroxyethyl 2-methylprop-2-enoate (HEMA), 2-hydroxypropyl 2-methylprop-2-enotate, 2-hydroxyethyl prop-2-enoate, 2-hydroxypropyl prop-2-enotate, N-(2-hydroxyethyl)methacrylamide, N-(2-hydroxypropyl)methacrylamide (HPMA), N-(2-hydroxyethyl)acrylamide, N-(2-hydroxypropyl)acrylamide, a telechelic N,N′-alkylenebisacrylamide), divinyl sulfone, and butadiene.

7. The ninhydrin-type sorbent according to claim 1 , wherein the polymer is a crosslinked polymer.

8. The ninhydrin-type sorbent according to claim 1 , wherein the urea binding capacity is the capacity that can be determined after incubation of the sorbent with an excess of urea in a solution at 70° C. for 24 hours.

9. A cartridge for use in a dialysis device, comprising a ninhydrin-type sorbent having a urea binding capacity of more than 2.3 mmol urea per gram of sorbent.

10. The cartridge according to claim 9 , wherein the cartridge is in a dialysis device.

11. The cartridge according to claim 10 , wherein the dialysis device is a hemodialysis device.

12. The cartridge according to claim 10 , wherein the dialysis device is a device for regeneration of peritoneal dialysate in peritoneal dialysis.

13. A method for removing nucleophilic waste solutes from a fluid, comprising the steps of:
i) providing a fluid comprising nucleophilic waste solutes, and
iia) contacting said fluid with a ninhydrin-type sorbent having a urea binding capacity of more than 2.3 mmol urea per gram of sorbent, or alternately
iib) contacting said fluid with a dialysis fluid through a membrane, wherein the dialysis fluid is in contact with a ninhydrin-type sorbent having a urea binding capacity of more than 2.3 mmol urea per gram of sorbent.

14. The method according to claim 13 , comprising the steps of:
i) providing a fluid comprising nucleophilic waste solutes, and
iia) contacting said fluid with a ninhydrin-type sorbent having a urea binding capacity of more than 2.3 mmol urea per gram of sorbent.

15. The method according to claim 13 , comprising the steps of:
i) providing a fluid comprising nucleophilic waste solutes, and
iib) contacting said fluid with a dialysis fluid through a membrane, wherein the dialysis fluid is in contact with a ninhydrin-type sorbent having a urea binding capacity of more than 2.3 mmol urea per gram of sorbent.

16. The method according to claim 13 , further comprising the step of:
iii) recovering the fluid.

17. The method according to claim 13 , wherein the method is a continuous process.

18. The method according to claim 13 , wherein the nucleophilic waste solutes are ammonia, urea, creatinine, small molecule organic amines, thiols, or alcohols, or wherein the fluid of step i) is blood or peritoneal dialysate.

Assignees

• Stichting Voor De Technische
• Univ Utrecht Holding Bv
• Umc Utrecht Holding Bv

Inventors

• Smakman Robert
• Hennink Wilhelmus Everhardus
• Gerritsen Karin Gerarda Frederika
• Jong Jacobus Adrianus Wilhelmus
• Van Nostrum Cornelus Franciscus

Classifications

• C08F212/22

  Oxygen · CPC title

• C08F2800/10

  as molar percentages · CPC title

• C08F212/32

  containing two or more rings · CPC title

• C08F8/20

  Halogenation · CPC title

• C08F8/06

  Oxidation · CPC title