Analysis system and analysis execution method

Patent metadata

Field	Value
Publication number	US-12306148-B2
Application number	US-202117514965-A
Country	US
Kind code	B2
Filing date	Oct 29, 2021
Priority date	Nov 5, 2020
Publication date	May 20, 2025
Grant date	May 20, 2025

Abstract

An analysis system is used to together with a sample supplier that supplies a sample, a detector that detects a sample and a display, and includes a plurality of channels arranged in parallel with one another and a display controller that causes a display to display a control screen in regard to control of the plurality of channels. Each channel includes a mobile phase supplier that supplies a mobile phase and an analysis column that separates a sample that has been supplied by the sample supplier into components and guides the components to the detector.

First claim

We claim:

1. An analysis system that is used together with a sample supplier that supplies a sample, a detector that detects a sample, and a display, the analysis system comprising:
a plurality of channels arranged in parallel with one another;
a flow-path switcher that selectively guides a sample supplied by the sample supplier to the plurality of channels;
a display controller that causes the display to display a control screen in regard to control of the plurality of channels;
a calibration curve setter that receives a selection between a first setting for creation of a calibration curve individually corresponding to one or more channels out of the plurality of channels and a second setting for creation of a calibration curve commonly corresponding to two or more channels out of the plurality of channels; and
a calibration curve creator that creates a calibration curve to be used by a channel of the plurality of channels in regard to the first setting or the second setting based on the first setting or the second setting selected in the calibration curve setter and a sample guided to the channel,
wherein each of the plurality of channels comprises:
a mobile phase supplier that supplies a mobile phase; and
an analysis column that separates the sample that has been supplied by the sample supplier into components and guides the components to the detector, and

wherein display controller causes the display to display a screen showing the first setting or the second setting selected in the calibration curve setter as the control screen.

2. The analysis system according to claim 1 , wherein
each of the plurality of channels further includes a high-pressure valve that is switchable between a first connection state in which a sample that has been supplied by the sample supplier is guided to the analysis column together with a mobile phase that has been supplied by the mobile phase supplier and a second connection state in which a sample that has been trapped in the analysis column is separated into components and guided to the detector by a mobile phase that has been supplied by the mobile phase supplier.

3. The analysis system according to claim 1 , wherein
the analysis system is further used together with a cleaning liquid supplier that supplies a cleaning liquid,
the flow-path switcher selectively guides the sample supplied by the sample supplier to the plurality of channels during the supply of the sample, and selectively guides a cleaning liquid supplied by the cleaning liquid supplier to the plurality of channels during cleaning of a flow path before or after the supply of the sample, and
each of the plurality of channels further includes a high-pressure valve that is switchable between a first connection state in which a mobile phase that has been supplied by the mobile phase supplier is guided to the analysis column through the sample supplier and a second connection state in which a cleaning liquid that has been supplied by the cleaning liquid supplier is guided to the sample supplier while a mobile phase that has been supplied by the mobile phase supplier is guided to the analysis column without going through the sample supplier.

4. The analysis system according to claim 1 , further comprising:
a determiner that determines whether each channel of the plurality of channels is in an unusable state due to an occurrence of error,
wherein the display controller causes the display to display a screen distinguishably showing a channel of the plurality of channels in a usable state and a channel of the plurality of channels in an unusable state due to the occurrence of error as the control screen.

5. An analysis system that is used together with a sample supplier that supplies a sample, a detector that detects a sample and a display, the analysis system comprising:
a plurality of channels arranged in parallel with one another;
a flow-path switcher that selectively guides the sample supplied by the sample supplier to the plurality of channels;
a display controller that causes the display to display a control screen in regard to control of the plurality of channels;
a batch generator that generates a batch file for controlling an analysis sequence based on information in regard to a sample to be used in any of the plurality of channels and an analysis condition;
an analysis executer that controls running of the flow-path switcher and the sample supplier based on the batch file generated by the batch generator; and
a power controller,
wherein each of the plurality of channels comprises:
a mobile phase supplier that supplies a mobile phase, and
an analysis column that separates the sample that has been supplied by the sample supplier into components and guides the components to the detector,

wherein the display controller causes the display to display a screen for receiving a first setting of a subject element, out of the sample supplier, the detector and the mobile phase supplier, to be individually powered off when execution of the batch file generated by the batch generator ends, and a second setting of a subject element, out of the sample supplier, the detector and the mobile phase supplier, to be individually powered off when the analysis executer is shut down, as the control screen, and
wherein the power controller individually powers off the sample supplier, the detector, or the mobile phase supplier in accordance with the first setting or the second setting received in the control screen.

6. The analysis system according to claim 5 ,
wherein the display controller causes the display to display a screen showing a table of the batch file generated by the batch generator and a flow-path diagram showing a current connection state of a channel of the plurality of channels, and also showing a portion of the batch file corresponding to a current stage of progress in the analysis sequence such that the portion is distinguishable from another portion of the batch file as the control screen.

7. An analysis system that is used together with a sample supplier that supplies a sample, a detector that detects a sample and a display, the analysis system comprising:
a plurality of channels arranged in parallel with one another;
a flow-path switcher that selectively guides the sample supplied by the sample supplier to the plurality of channels;
a display controller that causes the display to display a control screen in regard to control of the plurality of channels;
a data processor that processes detection data of a sample provided by the detector; and
a timing setter,
wherein each of the plurality of channels comprises:
a mobile phase supplier that supplies a mobile phase, and
an analysis column that separates the sample that has been supplied by the sample supplier into components and guides the components to the detector,

wherein the display controller causes the display to display a screen showing graphs of running periods of the sample supplier, any of the plurality of channels, the detector and the data processor as the control screen, and
wherein the timing setter sets a point in time at which a sample is to be injected by the sample supplier and a point in time at which a sample derived from the any of the plurality of channels is to be detected by the detector, and a period in which a signal output from the detector due to detection of a sample is to be processed in the data processor.

Assignees

• Shimadzu Corp

Inventors

• Ogawa Keisuke
• Sasaki Andy
• Hill Kerry
• Lee Timothy

Classifications

• G01N30/64

  Electrical detectors · CPC title

• H01J49/26

  Mass spectrometers or separator tubes · CPC title

• G01N2030/628

  Multiplexing, i.e. several columns sharing a single detector · CPC title

• G01N30/72 Primary

  Mass spectrometers {(mass spectrometers per se H01J49/00)} · CPC title

• G01N30/467 Primary

  all columns being identical · CPC title