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Method for preparing lurasidone hydrochloride
US12304906B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12304906-B2 |
| Application number | US-202017787369-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 7, 2020 |
| Priority date | Dec 24, 2019 |
| Publication date | May 20, 2025 |
| Grant date | May 20, 2025 |
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Abstract
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A method for preparing lurasidone hydrochloride by reacting lurasidone free alkali reacts with hydrochloric acid in a mixed solvent of an alcoholic solvent and an alkyl halide solvent.
First claim
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The invention claimed is: 1. A method for preparing lurasidone hydrochloride, comprising: heating and dissolving lurasidone free base in a mixed solvent of alcoholic solvent and dichloromethane, adding hydrochloric acid solution to carry out a salt-forming reaction; and cooling, crystallizing, filtering and drying to obtain lurasidone hydrochloride. 2. The method according to claim 1 , wherein the alcoholic solvent is one or more of methanol, ethanol, isopropanol, n-propanol, n-butanol, sec-butanol, isobutanol, ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 2,3-butanediol, 1,5-pentanediol, 1,6-hexanediol and glycerol. 3. The method according to claim 2 , wherein the alcoholic solvent is selected from the group consisting of methanol, ethanol, and isopropanol. 4. The method according to claim 1 , wherein the concentration of the hydrochloric acid solution is from 0.3% (w/w) to saturated concentration. 5. The method according to claim 4 , wherein the concentration of the hydrochloric acid solution is 15% to 38% (w/w). 6. The method according to claim 1 , wherein the molar ratio of hydrogen chloride in the hydrochloric acid solution to lurasidone free base is 20:1 to 1:1. 7. The method according to claim 6 , wherein the molar ratio of hydrogen chloride in the hydrochloric acid solution to lurasidone free base is 10:1 to 1:1. 8. The method according to claim 1 , wherein the hydrochloric acid solution is an aqueous hydrochloric acid solution, or a solution formed by mixing an aqueous hydrochloric acid solution with an appropriate amount of the alcoholic solvent. 9. The method according to claim 1 , wherein the mass-to-volume ratio of lurasidone free base to the alcoholic solvent in the reaction system is 1:5 to 1:50 (W/V). 10. The method according to claim 1 , wherein the mass-to-volume ratio of lurasidone free base to dichloromethane is 1:0.5 to 1:10 (W/V). 11. The method according to claim 9 , wherein the mass-to-volume ratio of lurasidone free base to the alcoholic solvent in the reaction system is 1:8 to 1:15 (W/V). 12. The method according to claim 10 , wherein the mass-to-volume ratio of lurasidone free base to dichloromethane is 1:1 to 1:4 (W/V).
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Classifications
Spiro-condensed systems · CPC title
- C07D417/12Primary
linked by a chain containing hetero atoms as chain links · CPC title
- C07D417/08Primary
linked by a carbon chain containing alicyclic rings · CPC title
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- What does patent US12304906B2 cover?
- A method for preparing lurasidone hydrochloride by reacting lurasidone free alkali reacts with hydrochloric acid in a mixed solvent of an alcoholic solvent and an alkyl halide solvent.
- Who is the assignee on this patent?
- Zhejiang Huahai Pharm Co Ltd, Shanghai Syncores Tech Inc Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07D417/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).