High-strength collagen sponge

Patent metadata

Field	Value
Publication number	US-12303613-B2
Application number	US-202218083598-A
Country	US
Kind code	B2
Filing date	Dec 19, 2022
Priority date	Dec 28, 2016
Publication date	May 20, 2025
Grant date	May 20, 2025

Abstract

To provide a collagen sponge excellent in mechanical strength and a production method for the collagen sponge. A collagen sponge including a porous construct having a pore structure, the collagen sponge having a tensile strength of 1 N or more and 5 N or less in every direction including a length direction and a width direction. The collagen sponge may be produced by a production method including the following steps: (1) a step of subjecting a collagen solution obtained by mixing collagen and a solvent to stirring and deaeration treatment; (2) a step of subjecting the collagen solution to freeze-dry treatment; and (3) a step of subjecting a dried collagen product after the freeze-dry treatment to insoluble treatment.

First claim

The invention claimed is:

1. A collagen sponge, comprising a porous construct having a pore structure, wherein a force (N) at a time of a start of breakage of the collagen sponge is 1 N or more and 5 N or less in any direction, wherein the collagen sponge has an average pore diameter falling within a range of 1 micron or more and less than 50 micron.

2. The collagen sponge according to claim 1 , wherein the force (N) at the time of a start of breakage is in the case where a cylindrical test piece having a diameter of 30 mm and a thickness of 5 mm brought into moist condition is pulled in a radial direction.

3. The collagen sponge according to claim 2 , wherein the collagen sponge is derived from atelocollagen and a cross-linking agent comprising an aldehyde compound or an epoxy compound.

4. The collagen sponge according to claim 2 , wherein the collagen sponge has a stress of 7 kPa or more and 30 kPa or less when loaded with 10 percent strain.

5. The collagen sponge according to claim 3 , wherein the collagen sponge has a stress of 7 kPa or more and 30 kPa or less when loaded with 10 percent strain.

6. The collagen sponge according to claim 1 , wherein the collagen sponge has a stress of 7 kPa or more and 30 kPa or less when loaded with 10 percent strain.

7. A collagen sponge, comprising a porous construct having a pore structure, wherein a force at a time of a start of breakage of the collagen sponge is 1 N or more and 5 N or less in any direction, the collagen sponge is derived from atelocollagen and a cross-linking agent comprising an aldehyde compound or an epoxy compound, the collagen sponge has an average pore diameter falling within a range of 1 micron or more and less than 50 micron and the collagen sponge has a stress of 7 kPa or more and 30 kPa or less when loaded with 10 percent strain.

8. A substitute for cartilage treatment, comprising the collagen sponge of claim 1 as a substrate.

9. The substitute for cartilage treatment according to claim 8 , wherein the cartilage treatment comprises fibrous cartilage regeneration treatment.

10. The substitute for cartilage treatment according to claim 9 , wherein the cartilage treatment comprises meniscus regeneration treatment.

Assignees

• Koken Kk
• Univ Osaka

Inventors

• Nakata Ken
• KANNO Gaku

Classifications

• C08J2389/00

  Characterised by the use of proteins; Derivatives thereof · CPC title

• C08J2201/048

  Elimination of a frozen liquid phase · CPC title

• C08J9/28

  by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum · CPC title

• A61L2430/06

  for cartilage reconstruction, e.g. meniscus · CPC title

• A61L27/56 Primary

  Porous materials, {e.g. foams or sponges} · CPC title