Film-forming composition containing surfactant or surfactant and salt as whitening agent

Patent metadata

Field	Value
Publication number	US-12303575-B2
Application number	US-202318371163-A
Country	US
Kind code	B2
Filing date	Sep 21, 2023
Priority date	Jul 4, 2018
Publication date	May 20, 2025
Grant date	May 20, 2025

Abstract

[Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide.
[Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.

First claim

We claim:

1. A film, comprising:
a film-forming polymer that is a cellulose derivative; and
a whitening agent that includes either a surfactant or both a surfactant and a water-soluble salt,
wherein the surfactant is a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, and/or a polyalkylene oxide derivative; and
wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

2. The film according to claim 1 , wherein the film is free from a white-color pigment.

3. The film according to claim 1 , wherein the cellulose derivative is hydroxypropyl methylcellulose (HPMC).

4. The film according to claim 1 , wherein (i) the fatty acid ester of polyhydric alcohol is a sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, or polyoxysorbitan fatty acid ester; and/or (ii) the polyalkylene oxide derivative is a polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, or polyoxyethylene fatty acid ester.

5. The film according to claim 1 , wherein the surfactant is polyoxyethylene polyoxypropylene glycol, polyethylene glycol, polypropylene glycol, sucrose monolaurate ester, sucrose palmitate ester, sorbitan monolaurate ester, or Polysorbate 80.

6. The film according to claim 1 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.7 parts by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

7. The film according to claim 1 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 1.0 part by weight to 30 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

8. The film according to claim 1 , wherein whiteness of the film is adjusted by a total amount of the surfactant within a range from 0.5 parts by weight to 15 parts by weight while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

9. The film according to claim 1 , wherein the water-soluble salt to be added is a sodium salt and/or a potassium salt and/or an ammonium salt.

10. The film according to claim 1 , wherein (i) the water-soluble salt to be added to the film-forming polymer is one or more salts selected from sodium malate, sodium succinate, sodium citrate, sodium polyphosphate, sodium bicarbonate, dipotassium hydrogenphosphate, disodium hydrogenphosphate, sodium dihydrogenphosphate, potassium carbonate, potassium dihydrogenphosphate, and sodium pyrophosphate dehydrate, and (ii) the whiteness of the film is changed by the total amount of the water-soluble salt within a range from 0.5 parts by weight to 30 parts by weight, while an amount, in dry weight, of the film-forming polymer is defined as 100 parts by weight.

11. The film according to claim 1 , further comprising a dye or a pigment to provide the film with a color other than white.

12. A capsule that is made of a film according to claim 1 and that is suitable for oral delivery.

13. The capsule according to claim 12 , wherein the capsule is filled with a drug, a cosmetic or a health food product.

14. The capsule according to claim 12 ,
wherein a combination of the film-forming polymer and the surfactant is a combination of:
hydroxypropyl methylcellulose (HPMC) and sucrose monolaurate ester;
hydroxypropyl methylcellulose (HPMC) and polyoxyethylene polyoxypropylene glycol;
hydroxypropyl methylcellulose (HPMC) and polyethylene glycol;
hydroxypropyl methylcellulose (HPMC) and polypropylene glycol;
hydroxypropyl methylcellulose (HPMC) and sucrose palmitate ester; or
hydroxypropyl methylcellulose (HPMC) and Polysorbate 80.

15. A film-forming composition forming a film according to claim 1 , the film-forming composition comprising:
the film-forming polymer dissolved in water, and
the whitening agent.

16. A method of manufacturing a film according to claim 1 or a capsule suitable for oral delivery, the method comprising:
providing a cellulose derivative as a film-forming polymer;
providing, as a whitening agent, either a surfactant or both a surfactant and a water-soluble salt;
combining the film-forming polymer and the whitening agent to provide a film-forming composition; and
forming the film or the capsule from the film-forming composition;
wherein the film and the capsule are free from a white-color pigment and the surfactant is a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, and/or a polyalkylene oxide derivative.

17. The method of claim 16 , wherein the cellulose derivative is hydroxypropyl methylcellulose (HPMC).

18. A capsule that is made of a film according to claim 11 and that is suitable for oral delivery.

19. The capsule according to claim 18 , wherein the capsule is filled with a drug, a cosmetic or a health food product.

20. The capsule according to claim 18 ,
wherein a combination of the film-forming polymer and the surfactant is a combination of:
hydroxypropyl methylcellulose (HPMC) and sucrose monolaurate ester;
hydroxypropyl methylcellulose (HPMC) and polyoxyethylene polyoxypropylene glycol;
hydroxypropyl methylcellulose (HPMC) and polyethylene glycol;
hydroxypropyl methylcellulose (HPMC) and polypropylene glycol;
hydroxypropyl methylcellulose (HPMC) and sucrose palmitate ester; or
hydroxypropyl methylcellulose (HPMC) and Polysorbate 80.

21. A method of manufacturing a capsule suitable for oral delivery according to claim 12 , the method comprising:
providing a cellulose derivative as a film-forming polymer;
providing, as a whitening agent, either a surfactant or both a surfactant and a water-soluble salt;
combining the film-forming polymer and the whitening agent to provide a film-forming composition; and
forming the film or the capsule from the film-forming composition;
wherein the film and the capsule are free from a white-color pigment and the surfactant is a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, and/or a polyalkylene oxide derivative.

Assignees

• Capsugel Belgium Nv

Inventors

• Sato Kaori
• Takubo Takahisa
• Doi Hitomi

Classifications

• A61K2800/92

  Oral administration · CPC title

• A61K2800/594

  Mixtures of polymers · CPC title

• A61K2800/43

  Pigments; Dyes · CPC title

• A61K2800/26

  Optical properties · CPC title

• A61K2800/10

  General cosmetic use · CPC title