Female-female adapter

Patent metadata

Field	Value
Publication number	US-12303463-B2
Application number	US-201917258833-A
Country	US
Kind code	B2
Filing date	Jul 11, 2019
Priority date	Jul 13, 2018
Publication date	May 20, 2025
Grant date	May 20, 2025

Abstract

The invention is directed to a female-female syringe adapter, related systems, and methods of using the female-female adapter. The female-female syringe adapter may be used with male nozzles of syringes and reconstitution devices when reconstituting a lyophilized powder. The female-female adapter also may be used to combine doses in a common syringe from mixed reconstitution products in a multi-chambered syringe.

First claim

What is claimed is:

1. A method of using a female-female adapter including a central lumen having a first end and a second end to reconstitute a lyophilized powder, the method comprising:
attaching a first end of a female-female adapter to a male nozzle of a syringe, the female-female adapter comprising wings extending parallel to the central lumen, each wing having a slat with a bow-tie shape, wherein each slat has an upper widest portion and a lower widest portion, and a narrowed middle portion between them;
pulling the female-female adapter axially, with the syringe and without touching the female-female adapter, such that the slats disengage from dual undercuts in a packaging, wherein each undercut engages the slat proximate the narrowed middle portion such that the lower widest portion of each slat is positioned below the respective undercut and the upper widest portion of each slat is positioned above the respective undercut;
removing the female-female adapter, with the female-female adapter attached to the syringe, from the packaging;
attaching a second end of the female-female adapter to a first component of a reconstitution device attached to a first vial, extracting a diluent from the first vial into the syringe;
disconnecting the syringe from the female-female adapter without touching the female-female adapter; and
reconstituting a lyophilized powder by attaching the male nozzle of the syringe to a second component of the reconstitution device attached to a second vial comprising the lyophilized powder and ejecting the diluent into the second vial.

2. The method of claim 1 , wherein the syringe has a male Luer lock nozzle.

3. The method of claim 1 , wherein the female-female adapter is attached without touch contamination.

4. A system comprising:
a female-female adapter comprising:
a central lumen having two ends, an inner surface, and an outer surface, the two ends opposite each other in a longitudinal direction, the two ends each capable of interlocking with a male end of a nozzle, and the central lumen having a central portion in the longitudinal direction; and
wings extending from the central portion and located at points opposite each other around a circumference of the central lumen, each wing forming a slat parallel to the central lumen, the slat having a first end and a second end wider than a narrowed middle section of the slat thereby forming a bow-tie shape; and

a packaging comprising a base, the base comprising dual undercuts, wherein each undercut is sized and shaped to engage a corresponding wing proximate the narrowed middle section such that a lower widest portion of the slat is positioned below the respective undercut, and an upper widest portion of the slat is positioned above the respective undercut, and wherein the female-female adapter is retained in an upright vertical orientation wherein the wings extend from the base in the longitudinal direction.

5. The system of claim 4 , wherein the wings of the female-female adapter further comprise ridges on a surface of the slat exterior to the central lumen.

6. The system of claim 4 , wherein the male end of the nozzle of the female-female adapter is a Luer lock.

7. The system of claim 4 , wherein the female-female adapter further comprises a filter disposed in the central lumen at the central portion and perpendicular to the longitudinal direction of the central lumen.

8. The system of claim 7 , wherein the filter of the female-female adapter is welded to the central lumen of the female-female adapter.

9. The system of claim 4 , wherein the packaging further comprises a reconstitution device arranged within the packaging.

10. The system of claim 9 , wherein the reconstitution device comprises a first component and a second component, each component comprising a base and a spike, each spike extending perpendicularly from a plane of the corresponding base.

11. The system of claim 10 , wherein the female-female adapter is positioned within the packaging beneath the reconstitution device and is partially nested within the reconstitution device such that one of the spikes of the reconstitution device is aligned with and extends into the central lumen of the female-female adapter.

Assignees

• Takeda Pharmaceuticals Co

Inventors

• Ariagno Scott Richard
• Schilling Mark
• Mathakari Amey
• Sanchez Daniel
• Blackledge Christopher

Classifications

• A61J1/2096 Primary

  Combination of a vial and a syringe for transferring or mixing their contents · CPC title

• A61M2005/3114

  Filling or refilling · CPC title

• A61M2209/06

  Packaging for specific medical equipment · CPC title

• A61M2205/75

  with filters · CPC title

• A61M2039/1077

  Adapters, e.g. couplings adapting a connector to one or several other connectors · CPC title