Hyaluronic acid-based zwitterionic polymer brush, preparation method thereof, and use thereof

Patent metadata

Field	Value
Publication number	US-12297300-B2
Application number	US-201817256387-A
Country	US
Kind code	B2
Filing date	Dec 12, 2018
Priority date	Jun 28, 2018
Publication date	May 13, 2025
Grant date	May 13, 2025

Abstract

Disclosed are a hyaluronic acid-based zwitterionic polymer brush, a preparation method thereof, and the use thereof. The structure of the zwitterionic polymer brush is represented by formula (I), wherein n is an integer from 60-150, x is an integer from 589-686, and y is an integer from 125-230. The above-mentioned zwitterionic polymer brush can delay the pathological progress of osteoarthritis, promote cartilage regeneration, and even treat osteoarthritis and improve conditions such as the generation of abraded fragments of implants such as joints and related diseases triggered thereby, and can be combined with cartilage repairing materials to improve the frictional mechanical properties thereof for achieving better repair results. Moreover, the above-mentioned zwitterionic polymer brush can selectively bind to proteins in cartilage and has an excellent lubricating effect. The present invention has the advantages of simple method, convenient operation, easy purification, high yield, and the like.

First claim

The invention claimed is:

1. A zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine, comprising the following structure capable of binding to fibronectin and type II collagen in cartilage:

wherein n is an integer from 60-150, x is an integer from 589-686, and y is an integer from 125-230.

2. A biomedicine comprising the zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine according to claim 1 .

3. A medicine for treating osteoarthritis comprising the zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine according to claim 1 , and combining with cartilage repairing materials to improve the frictional mechanical properties thereof.

4. A lubricant for improving the lubricating and frictional properties of implanted prostheses comprising the zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine according to claim 1 , and combining with cartilage repairing materials to improve the frictional mechanical properties thereof.

5. A biomimetic lubricant for improving the frictional property of cartilage repairing materials comprising the zwitterionic polymer brush based on hyaluronic acid and 2-methacryloyloxyethyl phosphorylcholine according to claim 1 .

Assignees

• Univ South China Tech

Inventors

• Ren Li
• Liu Sa
• Xie Renjian

Classifications

• C08G81/025

  containing polyether sequences · CPC title

• C08F130/02

  containing phosphorus · CPC title

• A61L31/042

  Polysaccharides · CPC title

• A61K31/728

  Hyaluronic acid · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title