Peptide compounds targeting PD-1 receptor as well as preparation and applications thereof

Patent metadata

Field	Value
Publication number	US-12297293-B2
Application number	US-202218568525-A
Country	US
Kind code	B2
Filing date	Jun 1, 2022
Priority date	Jun 10, 2021
Publication date	May 13, 2025
Grant date	May 13, 2025

Abstract

A peptide compound targeting a PD-1 receptor includes: a compound 1, a compound 2, a compound 3, a compound 4 and a compound 5; wherein the compounds 1-5 comprise amino acid sequences identical to SEQ ID NO: 1-5, respectively. A method for preparing the peptide compound targeting the PD-1 receptor includes steps of: using a solid-phase synthesis method for coupling amino acids of the compounds 1-5 to a solid-phase resin sequentially according to peptide sequences, and obtaining a target compound after cleavage by a cutting reagent, freeze-drying, and preparative purification. A method for preparing analgesic drugs includes using the peptide compound targeting the PD-1 receptor. The compounds 1-5 are capable of binding to PD-1, and have significant inhibitory effects on inflammatory pain and visceral pain under intrathecal administration; they are simple to synthesize, easy to be purified, and conducive to large-scale synthesis.

First claim

What is claimed is:

1. A peptide consisting of Ser Tyr Gly Gly Ala Asp Tyr Lys Arg (SEQ ID NO: 4).

Assignees

• Univ Nantong

Inventors

• Chen Gang
• Zhao Long
• Zhao Yayu
• Chen Ying
• Luo Hao
• Zhang Yonghui
• Wei Jinhuan

Classifications

• C07K1/20

  Partition-, reverse-phase or hydrophobic interaction chromatography · CPC title

• C07K1/061

  using protecting groups · CPC title

• C07K1/04

  on carriers {(C07K1/003, C07K1/006 take precedence)} · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61P29/00 Primary

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title