Functionalisation of medical devices

Patent metadata

Field	Value
Publication number	US-12296071-B2
Application number	US-202117564673-A
Country	US
Kind code	B2
Filing date	Dec 29, 2021
Priority date	Dec 30, 2020
Publication date	May 13, 2025
Grant date	May 13, 2025

Abstract

Methods of modifying medical devices and medical devices are disclosed. One embodiment of a method of modifying a medical device includes functionalizing a surface of the medical device using cold plasma. One embodiment of a medical device is obtained by a method of modifying a device that includes functionalizing a surface of the medical device using cold plasma.

First claim

The invention claimed is:

1. A method of modifying a medical device, the method comprising:
functionalizing a surface of the medical device using cold plasma,
wherein:
functionalizing the surface of the medical device using cold plasma comprises contacting the surface with cold plasma to provide a plasma-treated surface and performing cold plasma treatment at a temperature between 15° C. and 40° C.,
contacting the surface with cold plasma comprises introducing a monomer to cold plasma to create monomer plasma and applying the monomer plasma to the surface to provide the plasma-treated surface,
the method further comprises mixing the monomer with a precursor gas stream consisting of nitrogen gas,
functionalizing the surface using cold plasma comprises functionalizing the plasma-treated surface with a polymer, and
the polymer or the monomer is a polyalkylene glycol having a reactive end group.

2. The method of claim 1 , wherein functionalizing the plasma-treated surface with the polymer includes plasma polymerizing the monomer plasma onto the plasma-treated surface.

3. The method of claim 1 , wherein:
contacting the surface with cold plasma comprises treating the surface with cold plasma to create reactive sites or polymerization initiation sites on the surface; and
functionalizing the plasma-treated surface with the polymer comprises reacting, simultaneously or subsequently, a polymer or a monomer with the plasma-treated surface to functionalize the surface with the polymer or the monomer.

4. A method of modifying a medical device, the method comprising:
functionalizing a surface of the medical device using cold plasma,
wherein:
functionalizing the surface of the medical device using cold plasma comprises contacting the surface with cold plasma to provide a plasma-treated surface and performing cold plasma treatment at a temperature between 15° C. and 40° C.,
contacting the surface with cold plasma comprises introducing a monomer to cold plasma to create monomer plasma and applying the monomer plasma to the surface to provide the plasma-treated surface,
the method further comprises mixing the monomer with a precursor gas stream consisting of nitrogen gas,
functionalizing the surface using cold plasma comprises functionalizing the plasma-treated surface with a polymer,
the polymer or the monomer is a polyalkylene glycol having a reactive end group, and
wherein the polymer or the monomer is selected from the group including an acrylate-functionalized polyalkylene glycol and an alkylacrylate polyalkylene glycol.

5. A method of modifying a medical device, the method comprising:
functionalizing a surface of the medical device using cold plasma,
wherein:
functionalizing the surface of the medical device using cold plasma comprises contacting the surface with cold plasma to provide a plasma-treated surface and performing cold plasma treatment at a temperature between 15° C. and 40° C.,
contacting the surface with cold plasma comprises introducing a monomer to cold plasma to create monomer plasma and applying the monomer plasma to the surface to provide the plasma-treated surface,
the method further comprises mixing the monomer with a precursor gas stream consisting of nitrogen gas,
functionalizing the surface using cold plasma comprises functionalizing the plasma-treated surface with a polymer,
the polymer or the monomer is a polyalkylene glycol having a reactive end group,
wherein the polymer or the monomer is selected from the group including an acrylate-functionalized polyalkylene glycol and an alkylacrylate polyalkylene glycol, and
wherein the polymer or the monomer is selected from the group including an acrylate- or methacrylate-functionalized polyethylene or polypropylene glycol.

6. The method of claim 1 , further comprising creating a hydrophilic surface or a hydrophobic surface.

7. The method of claim 1 , wherein functionalizing the surface of the medical device using cold plasma comprises performing cold plasma treatment at (i) a pressure of between 0.5 and 1500 mbar and (ii) a plasma power of between 1 W and 2000 W.

8. The method of claim 7 , wherein functionalizing the surface of the medical device using cold plasma comprises performing cold plasma treatment at a plasma power of between 5 W and 100 W.

9. A method of modifying a medical device, the method comprising:
combining a monomer with a cold plasma;
creating a monomer plasma of the monomer; and
graft polymerizing the monomer plasma onto a surface of the medical device,
wherein combining the monomer with the cold plasma comprises combining a monomer having the following formula with the cold plasma:

10. The method of claim 9 , further comprising mixing the monomer with a precursor fluid or plasma gas selected from the group including hydrogen, oxygen, nitrogen, air, ammonia, argon, helium, carbon dioxide, water, methane, ethane, propane, butane, or any mixture thereof.

11. The method of claim 9 , wherein the monomer is a polyalkylene glycol having a reactive end group.

12. The method of claim 11 , wherein the monomer is selected from the group including an acrylate-functionalized polyalkylene glycol and an alkylacrylate polyalkylene glycol.

13. The method of claim 9 , further comprising creating a hydrophilic surface or a hydrophobic surface.

14. A method of modifying a medical device, the method comprising:
combining a monomer with a cold plasma;
creating a monomer plasma of the monomer; and
graft polymerizing the monomer plasma onto a surface of the medical device to create a hydrophilic surface or a hydrophobic surface,
wherein graft polymerizing the monomer plasma onto the surface of the medical device comprises performing cold plasma treatment at a temperature between 15° C. and 40° C.,
wherein combining the monomer with the cold plasma comprises mixing the monomer with a precursor gas stream consisting of nitrogen gas, and
wherein the monomer is a polyalkylene glycol having a reactive end group.

Assignees

• Convatec Technologies Inc

Inventors

• Pytel Rachel Zimet
• Carty Neal Robert

Classifications

• B05D3/147

  Curing · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• B05D3/148

  affecting the surface properties of the coating · CPC title

• B05D2518/00

  Other type of polymers · CPC title